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Title: Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval
Author: Zhang, Zhi ; Gong, Neng ; null(王 伟) ; Xu, Lin ; Xu, Tian-Le(徐天乐)
Source: CEREBRAL CORTEX
Issued Date: 2008
Volume: 18, Issue:10, Pages:2391-2401
Keyword: D-serine ; glia ; hippocampus ; long-term depression ; memory retrieval ; NMDA receptor ; METHYL-D-ASPARTATE ; SYNAPTIC PLASTICITY ; NUCLEUS-ACCUMBENS ; RECEPTOR ; BRAIN ; GLIA ; POTENTIATION ; RACEMASE ; SLICES ; NEUROTRANSMISSION
Subject: Neurosciences & Neurology
Corresponding Author: Xu, TL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn
English Abstract: D-Serine, the endogenous coagonist of N-methyl-D-aspartate receptors (NMDARs), is considered to be an important gliotransmitter, and is essential for the induction of long-term potentiation. However, less is known about the role of D-serine in another form of synaptic plasticity, long-term depression (LTD). In this study, we found that exogenous D-serine regulated LTD in the hippocampal CA1 region in a "bell-shaped" concentration-dependent manner through regulating the function of NMDARs in the same manner, whereas endogenous D-serine was activity-dependently released and, in turn, contributed to the induction of LTD during low-frequency stimulation. Furthermore, impairing glial functions with sodium fluoroacetate (NaFAC) reduced the magnitude of LTD, which could be restored by exogenous D-serine, indicating that endogenous D-serine is mainly glia-derived during LTD induction. More interestingly, similar to the effects on LTD, exogenous D-serine enhanced spatial memory retrieval in the Morris water maze in a bell-shaped dose-dependent manner and rescued the NaFAC-induced impairment of memory retrieval, suggesting links between LTD and spatial memory retrieval. Our study thus provides direct evidence of the bell-shaped D-serine actions on hippocampal LTD and spatial memory retrieval, and underscores the importance of D-serine in synaptic plasticity, learning, and memory.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1697
Appears in Collections:神经所(总)_期刊论文
视知觉机制研究组_期刊论文

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Zhang, Zhi; Gong, Neng; Wang, Wei; Xu, Lin; Xu, Tian-Le.Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval,CEREBRAL CORTEX,2008,18(10):2391-2401
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