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Title: Circadian modulation of light-induced locomotion responses in Drosophila melanogaster
Author: Lu, B. ; Liu, W. ; Guo, F. ; null(郭爱克)
Source: GENES BRAIN AND BEHAVIOR
Issued Date: 2008
Volume: 7, Issue:7, Pages:730-739
Keyword: arrhythmic mutants ; circadian rhythm ; Drosophila ; light ; locomotion responses ; normal masking ; paradoxical masking ; PIGMENT-DISPERSING FACTOR ; LATERAL NEURONS ; CLOCK PROTEIN ; FRUIT-FLIES ; RHYTHMS ; GENE ; PERIOD ; CRYPTOCHROME ; MASKING ; OSCILLATOR
Subject: Behavioral Sciences ; Neurosciences & Neurology
Corresponding Author: Guo, A (reprint author), Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China,akguo@ion.ac.cn
English Abstract: The relationship between light and the circadian system has long been a matter of discussion. Many studies have focused on entrainment of light with the internal biological clock. Light also functions as an environmental stimulus that affects the physiology and behaviour of animals directly. In this study, we used light as an unexpected stimulus for flies at different circadian times. We found that wildtype flies showed circadian changes in light-induced locomotion responses. Elevation of locomotor activity by light occurred during the subjective night, and performance in response to light pulses declined to trough during the subjective day. Moreover, arrhythmic mutants lost the rhythm of locomotion responses to light, with promotion of activity by light in timeless(01) mutants and inhibition of activity by light in Clock(ar) mutants. However, neither ablation of central oscillators nor disturbance of the functional clock inside compound eyes was sufficient to disrupt the rhythm of light responses. We show that, compound eyes, which have been identified as the control point for normal masking (promotion of activity by light), are sufficient but not necessary for paradoxical masking (suppression of activity by light) under high light intensity. This, taken together with the clear difference of light responses in wildtype flies, suggests that two different masking mechanisms may underlie the circadian modulation of light-induced locomotion responses.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1698
Appears in Collections:神经所(总)_期刊论文
学习与记忆研究组_期刊论文

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Lu, B.; Liu, W.; Guo, F.; Guo, A..Circadian modulation of light-induced locomotion responses in Drosophila melanogaster,GENES BRAIN AND BEHAVIOR,2008,7(7):730-739
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