中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Differential effects of thiopental and pentobarbital on spinal GABA(A) receptors
Author: Yang, Chuan-Xiu ; Zhang, Xiao-Bing ; Gong, Neng ; Wang, Meng-Ya ; Xu, Tian-Le(徐天乐)
Source: NEUROCHEMICAL RESEARCH
Issued Date: 2008
Volume: 33, Issue:10, Pages:2159-2165
Keyword: thiopental ; pentobarbital ; GABA(A) receptors ; mechanically dissociated neuron ; spinal cord dorsal horn ; GATED ION CHANNELS ; DORSAL-HORN NEURONS ; IN-VITRO ; ETOMIDATE ; ANESTHETICS ; MODULATION ; ACTIVATION ; MECHANISMS ; SUBUNIT ; SITES
Subject: Biochemistry & Molecular Biology ; Neurosciences & Neurology
Corresponding Author: Xu, TL (reprint author), Med Coll Soochow Univ, Dept Neurobiol, 199 Ren Ai Rd,Suzhou Ind Pk, Suzhou 215123, Peoples R China,tlxu@ion.ac.cn
English Abstract: General anesthetics thiopental and pentobarbital possess very similar chemical structures whereas their clinical potency is quite different. The underlying molecular mechanism is not fully understood. This study was designed to assess the differential effects of thiopental and pentobarbital on GABA(A) receptors of mechanically dissociated rat spinal dorsal horn neurons by using whole-cell patch-clamp technique. Pentobarbital, at a concentration of 30 mu M, which markedly enhanced sub-saturated GABA-induced current (I (GABA)), had no effect on thiopental-induced maximal current. Similarly, the pentobarbital-induced maximal current was also not affected by 30 mu M thiopental. Moreover, a linear summation of thiopental-induced maximal current and pentobarbital-induced sub-maximal current was observed. In addition, pentobarbital failed to further enhance I (GABA) in the presence of thiopental at a concentration with maximal modulatory effects on I (GABA), and vice versa. Our results thus suggest that thiopental and pentobarbital might exert the GABA mimetic effects independently, but share a common mechanism to produce the GABA modulatory effects.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1700
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Yang-2008-Differential effects.pdf(402KB)----开放获取View Download

Recommended Citation:
Yang, Chuan-Xiu; Zhang, Xiao-Bing; Gong, Neng; Wang, Meng-Ya; Xu, Tian-Le.Differential effects of thiopental and pentobarbital on spinal GABA(A) receptors,NEUROCHEMICAL RESEARCH,2008,33(10):2159-2165
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Chuan-Xiu]'s Articles
[Zhang, Xiao-Bing]'s Articles
[Gong, Neng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Chuan-Xiu]‘s Articles
[Zhang, Xiao-Bing]‘s Articles
[Gong, Neng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Yang-2008-Differential effects.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!