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Title: amnesiac regulates sleep onset and maintenance in Drosophila melanogaster
Author: Liu, Weijie ; Guo, Fang ; Lu, Beika ; Guo, Aike
Source: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Issued Date: 2008
Volume: 372, Issue:4, Pages:798-803
Keyword: aging ; amnesiac ; Drosophila ; sleep fragmentation ; sleep onset ; MUSHROOM BODIES ; GENE-PRODUCT ; MEMORY ; MODULATION ; REST ; AGE ; MUTANTS ; WAKING ; BRAIN
Subject: Biochemistry & Molecular Biology ; Biophysics
Corresponding Author: Guo, AK (reprint author), Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, 15 Datun Rd, Beijing 100101, Peoples R China,akguo@ion.ac.cn
English Abstract: The adenylate cyclase/cAMP signaling pathway and adult mushroom bodies (MBs) have been shown to play an important role in sleep regulation in Drosophila. The amnesiac (amn) gene, encodes a neuropeptide that is homologous with vertebrate pituitary adenylate cyclase-activating peptide (PACAP), is expressed in dorsal paired medial (DPM) neurons and is required for the middle-term memory (MTM) in flies. However, the role of amn on regulation of sleep is as yet unknown. Here we provide evidence that amn plays a Major role on sleep maintenance and onset in Drosophila. Flies with the amnesiac allele, loss-of-function amn(x8) mutation, showed a fragmented sleep pattern and short sleep latency. Moreover, homeostatic regulation was disrupted in amn(x8) mutants after sleep deprivation. Sleep maintenance was also influenced by disruption of neurotransmission in DPM neurons with increased sleep bout number and decreased sleep bout length. Furthermore, age-related sleep fragmentation and initiation were inhibited in amnx8 mutant flies. These data suggest that amn is required in initiation and maintenance of sleep. (c) 2008 Elsevier Inc. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1703
Appears in Collections:神经所(总)_期刊论文

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Liu, Weijie; Guo, Fang; Lu, Beika; Guo, Aike.amnesiac regulates sleep onset and maintenance in Drosophila melanogaster,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,372(4):798-803
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