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Title: ZNF23 induces apoptosis in human ovarian cancer cells
Author: Huang, Chuanxin ; Yang, Shenglian ; Ge, Ruillang ; Sun, Hongwei ; Shen, Feng ; null(王以政)
Source: CANCER LETTERS
Issued Date: 2008
Volume: 266, Issue:2, Pages:135-143
Keyword: ZNF23 ; Bcl-X-L ; apoptosis ; CASPASE ACTIVATION ; IN-VITRO ; BCL-X ; INHIBITOR ; PROTEIN ; DEATH ; PROLIFERATION ; CYCLE
Subject: Oncology
Corresponding Author: Shen, F (reprint author), Mil Med Coll 2, Eastern Hepalobiliary Surg Hosp, Div Comprehens Treatment, Shanghai 200438, Peoples R China,shenfengdfgd@yahoo.com.cn ; yzwang@ion.ac.cn
English Abstract: We recently reported that the level of ZNF23, a KRAB-containing zinc finger protein, is reduced in human cancers and it inhibits cell growth by inducing Cell Cycle arrest. Here we showed that ZNF23 also induces apoptosis in ovarian cancer cells. The protein level of ZNF23 in ovarian cancers was greatly down-regulated compared with that in the normal ovaries. Introduction of ZNF23 into ovarian cancer cells led to apoptosis as demonstrated by activation of caspase-3, nuclear condensation and formation of a sub-G1 peak. This apoptotic process was correlated with loss in mitochondrial membrane potential, cytochrome c release and caspase-9 activation. Furthermore, ZNF23 induced apoptosis partially via down-regulation of Bcl-X-L, Thus, our results suggest that ZNF23 may also induce apoptosis to suppress tumor cell growth and points to the possibility that its down-regulation might facilitate ovarian cancer cell survival. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1704
Appears in Collections:神经所(总)_期刊论文
神经信号转导研究组_期刊论文

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Huang, Chuanxin; Yang, Shenglian; Ge, Ruillang; Sun, Hongwei; Shen, Feng; Wang, Yizheng.ZNF23 induces apoptosis in human ovarian cancer cells,CANCER LETTERS,2008,266(2):135-143
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