中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics
Author: Yu, Yuguo ; null(舒友生) ; McCormick, David A.
Source: JOURNAL OF NEUROSCIENCE
Issued Date: 2008
Volume: 28, Issue:29, Pages:7260-7272
Keyword: axon ; kink ; Hodgkin-Huxley ; pyramidal cell ; spike timing ; Na+ channels ; NEURONS IN-VIVO ; AXON INITIAL SEGMENT ; NEOCORTICAL PYRAMIDAL NEURONS ; SYNAPTIC CONDUCTANCES ; COINCIDENCE DETECTION ; CELLS ; CHANNELS ; MODEL ; DENDRITES ; CORTEX
Subject: Neurosciences & Neurology
Corresponding Author: McCormick, DA (reprint author), Yale Univ, Sch Med, Kavli Inst Neurosci, Dept Neurobiol, 333 Cedar St, New Haven, CT 06510 USA,david.mccormick@yale.edu
English Abstract: Neocortical action potential responses in vivo are characterized by considerable threshold variability, and thus timing and rate variability, even under seemingly identical conditions. This finding suggests that cortical ensembles are required for accurate sensorimotor integration and processing. Intracellularly, trial-to-trial variability results not only from variation in synaptic activities, but also in the transformation of these into patterns of action potentials. Through simultaneous axonal and somatic recordings and computational simulations, we demonstrate that the initiation of action potentials in the axon initial segment followed by backpropagation of these spikes throughout the neuron results in a distortion of the relationship between the timing of synaptic and action potential events. In addition, this backpropagation also results in an unusually high rate of rise of membrane potential at the foot of the action potential. The distortion of the relationship between the amplitude time course of synaptic inputs and action potential output caused by spike backpropagation results in the appearance of high spike threshold variability at the level of the soma. At the point of spike initiation, the axon initial segment, threshold variability is considerably less. Our results indicate that spike generation in cortical neurons is largely as expected by Hodgkin-Huxley theory and is more precise than previously thought.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1712
Appears in Collections:神经所(总)_期刊论文
神经网络功能研究组_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Yu-2008-Cortical action pote.pdf(5560KB)----开放获取View Download

Recommended Citation:
Yu, Yuguo; Shu, Yousheng; McCormick, David A..Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics,JOURNAL OF NEUROSCIENCE,2008,28(29):7260-7272
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yu, Yuguo]'s Articles
[Shu, Yousheng]'s Articles
[McCormick, David A.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yu, Yuguo]‘s Articles
[Shu, Yousheng]‘s Articles
[McCormick, David A.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Yu-2008-Cortical action pote.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!