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Title: TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway
Author: Tai, Yilin ; Feng, Shengjie ; Ge, Ruiliang ; Du, Wanlu ; Zhang, Xiaoxing ; He, Zhuohao ; null(王以政)
Source: JOURNAL OF CELL SCIENCE
Issued Date: 2008
Volume: 121, Issue:14, Pages:2301-2307
Keyword: TRPC channels ; dendritic development ; Ca(2+)/calmodulin-dependent kinase IV (CaMKIV) ; CREB ; RAT SUBSTANTIA-NIGRA ; PROTEIN-KINASE-IV ; MEDIATED TRANSCRIPTION ; CELLULAR-LOCALIZATION ; NEUROTROPHIC FACTOR ; TRANSIENT RECEPTOR ; BINDING PROTEIN ; CALCIUM ; ACTIVATION ; BRAIN
Subject: Cell Biology
Corresponding Author: Wang, YZ (reprint author), Chinese Acad Sci, Lab Neural Signal Transduct, Inst Neurosci,Grad Sch, Shanghai Inst Biol Sci,State Key Lab Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn
English Abstract: The canonical transient receptor potential channels (TRPCs) are Ca(2+)-permeable nonselective cation channels with various physiological functions. Here, we report that TRPC6, a member of the TRPC family, promotes hippocampal neuron dendritic growth. The peak expression of TRPC6 in rat hippocampus was between postnatal day 7 and 14, a period known to be important for maximal dendritic growth. Overexpression of TRPC6 increased phosphorylation of Ca(2+)/calmodulin-dependent kinase IV (CaMKIV) and cAMP-response-element binding protein (CREB) and promoted dendritic growth in hippocampal cultures. Downregulation of TRPC6 by short hairpin RNA interference against TRPC6 suppressed phosphorylation of both CaMKIV and CREB and impaired dendritic growth. Expressing a dominant-negative form of CaMKIV or CREB blocked the TRPC6-induced dendritic growth. Furthermore, inhibition of Ca(2+) influx suppressed the TRPC6 effect on dendritic growth. Finally, in TRPC6 transgenic mice, the phosphorylation of CaMKIV and CREB was enhanced and the dendritic growth was also increased. In conclusion, TRPC6 promoted dendritic growth via the CaMKIV-CREB pathway. Our results thus revealed a novel role of TRPC6 during the development of the central nervous system (CNS).
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1715
Appears in Collections:神经所(总)_期刊论文
神经信号转导研究组_期刊论文

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Tai, Yilin; Feng, Shengjie; Ge, Ruiliang; Du, Wanlu; Zhang, Xiaoxing; He, Zhuohao; Wang, Yizheng.TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway,JOURNAL OF CELL SCIENCE,2008,121(14):2301-2307
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