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Title: Critical role of TRPC6 channels in the formation of excitatory synapses
Author: Zhou, Jian ; Du, Wanlu ; Zhou, Kechun ; Tai, Yilin ; null(王以政) ; Jia, Yichang ; Ding, Yuqiang ; null(王以政)
Source: NATURE NEUROSCIENCE
Issued Date: 2008
Volume: 11, Issue:7, Pages:741-743
Keyword: DENDRITIC SPINES ; MEMORY ; ACTIVATION ; BDNF
Subject: Neurosciences & Neurology
Corresponding Author: Wang, YZ (reprint author), Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, Lab Neural Signal Transduct, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn
English Abstract: The transient receptor potential canonical (TRPC) channels are Ca(2+)-permeable, nonselective cation channels with different biological functions, but their roles in brain are largely unknown. Here we report that TRPC6 was localized to excitatory synapses and promoted their formation via a CaMKIV-CREB-dependent pathway. TRPC6 transgenic mice showed enhancement in spine formation, and spatial learning and memory in Morris water maze. These results reveal a previously unknown role of TRPC6 in synaptic and behavioral plasticity.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1722
Appears in Collections:神经所(总)_期刊论文
神经信号转导研究组_期刊论文

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Recommended Citation:
Zhou, Jian; Du, Wanlu; Zhou, Kechun; Tai, Yilin; Yao, Hailan; Jia, Yichang; Ding, Yuqiang; Wang, Yizheng.Critical role of TRPC6 channels in the formation of excitatory synapses,NATURE NEUROSCIENCE,2008,11(7):741-743
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