Wang, YZ (reprint author), Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, Lab Neural Signal Transduct, Shanghai 200031, Peoples R China,email@example.com
The transient receptor potential canonical (TRPC) channels are Ca(2+)-permeable, nonselective cation channels with different biological functions, but their roles in brain are largely unknown. Here we report that TRPC6 was localized to excitatory synapses and promoted their formation via a CaMKIV-CREB-dependent pathway. TRPC6 transgenic mice showed enhancement in spine formation, and spatial learning and memory in Morris water maze. These results reveal a previously unknown role of TRPC6 in synaptic and behavioral plasticity.
Zhou, Jian; Du, Wanlu; Zhou, Kechun; Tai, Yilin; Yao, Hailan; Jia, Yichang; Ding, Yuqiang; Wang, Yizheng.Critical role of TRPC6 channels in the formation of excitatory synapses,NATURE NEUROSCIENCE,2008,11(7):741-743