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Title: Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation
Author: Yao, Yi-Qun ; Ding, Xia ; Jia, Yi-Chang ; Huang, Chuan-Xin ; Wang, Yi-Zheng ; Xu, Ying-Hui
Source: CANCER LETTERS
Issued Date: 2008
Volume: 264, Issue:1, Pages:127-134
Keyword: beta-elemene ; cell cycle ; p38 MAPK ; SMOOTH-MUSCLE-CELLS ; PROTEIN-KINASE ; CYCLE ARREST ; IN-VITRO ; TRANSCRIPTIONAL REPRESSOR ; CANCER CELLS ; APOPTOSIS ; PATHWAY ; INVOLVEMENT ; EXPRESSION
Subject: Oncology
Corresponding Author: Xu, YH (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn ; xuyh@dmu-1.com
English Abstract: beta-Elemene, a natural plant drug extracted from Curcuma wenyujin, has been used as an antitumor drug for different tumors, including glioblastoma. However, the mechanism of its anti-tumor effect is largely unknown. Here we report that anti-proliferation of glioblastoma cells induced by beta-elemene was dependent on p38 MAPK activation. Treatment of glioblastoma cell lines with beta-elemene, led to phosphorylation of p38 MAPK, cell-cycle arrest in G0/G1 phase and inhibition of proliferation of these cells. Inhibition of p38 MAPK reversed beta-elemene-mediated anti-proliferation effect. Furthermore, the growth of glioblastoma cell-transplanted tumors in nude mice was inhibited by intraperitoneal injection of beta-elemene. Taken together, our findings indicate that activation of p38 MAPK is critical for the anti-proliferation effect of P-elemene and that p38 MAPK might be a putative pharmacological target for glioblastoma therapy. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1724
Appears in Collections:神经所(总)_期刊论文

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Yao, Yi-Qun; Ding, Xia; Jia, Yi-Chang; Huang, Chuan-Xin; Wang, Yi-Zheng; Xu, Ying-Hui.Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation,CANCER LETTERS,2008,264(1):127-134
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