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Title: Increased dopaminergic signaling impairs aversive olfactory memory retention in Drosophila
Author: Zhang, Shixing ; Yin, Yan ; Lu, Huimin ; Guo, Aike
Source: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Issued Date: 2008
Volume: 370, Issue:1, Pages:82-86
Keyword: drosophila ; dopamine ; olfactory memory ; NEURONS ; MELANOGASTER ; TRANSPORTER ; ACTIVATION ; EXPRESSION ; COCAINE
Subject: Biochemistry & Molecular Biology ; Biophysics
Corresponding Author: Guo, A (reprint author), Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, 15 Datun Rd,Chaoyang Dist, Beijing 100101, Peoples R China,akguo@ion.ac.cn
English Abstract: Dopamine is necessary for the aversive olfactory associative memory formation in Drosophila, but its effect on other stages of memory is not known. Herein, we studied the effect of enhanced dopaminergic signaling on aversive olfactory memory retention in flies. We used L-3,4-dihydroxyphenylalanine (L-DOPA) to elevate dopamine levels: L-DOPA-treated flies exhibited a normal learning performance, but a decrease in I-h memory. Dopamine transporter (DAT) mutant flies or flies treated with the DAT inhibitor desipramine exhibited poor memory retention, Flies subjected to heat stress after training exhibited a decrease in memory. Memory was restored by blocking dopaminergic neuronal output during heat stress, suggesting that dopamine is involved in heat stress-induced memory impairment in flies. Taken together, our findings suggest that increased dopaminergic signaling impairs aversive olfactory memory retention in flies. (c) 2008 Elsevier Inc. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1727
Appears in Collections:神经所(总)_期刊论文

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Zhang, Shixing; Yin, Yan; Lu, Huimin; Guo, Aike.Increased dopaminergic signaling impairs aversive olfactory memory retention in Drosophila,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,370(1):82-86
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