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Title: Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio
Author: Dong, Zhifang ; Zhong, Weixia ; Tian, Meng ; Han, Huili ; Mao, Rongrong ; Cao, Jun ; Sui, Nan ; Xu, Tianle(徐天乐) ; Luo, Jianhong ; Xu, Lin
Source: BRAIN RESEARCH
Issued Date: 2008
Volume: 1207, Issue:pt 1, Pages:164-173
Keyword: opiate withdrawal ; stress ; delayed-escape behaviour ; long-term potentiation ; NR2A ; NR2B ; hippocampus ; LONG-TERM POTENTIATION ; ADRENAL-STEROID RECEPTORS ; SYNAPTIC PLASTICITY ; SPATIAL MEMORY ; IN-VIVO ; NUCLEUS-ACCUMBENS ; STRESS ; DEPRESSION ; ADDICTION ; RETRIEVAL
Subject: Neurosciences & Neurology
Corresponding Author: Xu, L (reprint author), Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China,lxu@vip.163.com
English Abstract: Repeated low-dose morphine treatment facilitates delayed-escape behaviour of hippocampus-dependent Morris water maze and morphine withdrawal influences hippocampal NMDA receptor-dependent synaptic plasticity. Here, we examined whether and how morphine withdrawal influenced delayed-escape behaviour and NR2A/2B expression ratio of hippocampal synaptosomes. We found that both delayed-escape behaviour and NR2A/2B expression ratio showed an inverted-U curve and peaked on 4-day withdrawal during a 20-day withdrawal period. Furthermore, treatment of the glucocorticoid receptor antagonist RU38486 for 3 days reduced delayed-escape behaviour and NR2A/2B ratio on 4-day withdrawal to a level similar to those of 18-h withdrawal. In contrast, elevated-platform stress enabled delayed-escape behaviour of 18-h withdrawal to a higher level similar to that of 4-day withdrawal, but had no significant effect on the NR2A/2B ratio. Similar behavioural effects were also found after intrahippocampal infusions of the NMDAR antagonist AP-5 or NR2B-containing NMDAR antagonist Ro25-6981 for 3 days. These findings suggest that delayed-escape behaviour enabled by repeated low-dose morphine treatment may be a useful and simple rat model for studying addictive memories to be retrieved by stress exposure. (C) 2008 Elsevier B.V. All rights reserved.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1730
Appears in Collections:神经所(总)_期刊论文

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Dong, Zhifang; Zhong, Weixia; Tian, Meng; Han, Huili; Mao, Rongrong; Cao, Jun; Sui, Nan; Xu, Tianle; Luo, Jianhong; Xu, Lin.Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio,BRAIN RESEARCH,2008,1207():164-173
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