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Title: The Kv4.2 mediates excitatory activity-dependent regulation of neuronal excitability in rat cortical neurons
Author: Shen, Bin ; Zhou, Kechun ; Yang, Shenglian ; Xu, Tianle(徐天乐) ; null(王以政)
Source: JOURNAL OF NEUROCHEMISTRY
Issued Date: 2008
Volume: 105, Issue:3, Pages:773-783
Keyword: excitability ; glutamate ; Kv4.2 ; NMDA receptor ; translocation ; ACTIVATED PROTEIN-KINASE ; LONG-TERM POTENTIATION ; INTRINSIC EXCITABILITY ; PYRAMIDAL NEURONS ; SYNAPTIC PLASTICITY ; K+ CHANNELS ; DENDRITIC EXCITABILITY ; HOMEOSTATIC PLASTICITY ; POTASSIUM CURRENTS ; LTP INDUCTION
Subject: Biochemistry & Molecular Biology ; Neurosciences & Neurology
Corresponding Author: Shen, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Key Lab Neurobiol,Grad Sch, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn
English Abstract: Neuronal excitability can cooperate with synaptic transmission to control the information storage. This regulation of neuronal plasticity can be affected by alterations in neuronal inputs and accomplished by modulation of voltage-dependent ion channels. In this study, we report that enhanced excitatory input negatively regulated neuronal excitability. Enhanced excitatory input by glutamate, electric field stimulation or high K+ increased transient outward K+ current, whereas did not affect the delayed rectifier K+ current in rat cultured cortical neurons. Both the voltage-dependent K+ channel 4.2 and 4.3 subunits contributed to the increase. The increase in the K+ current density by Kv4.2 was ascribed to its cytoplasmic membrane translocation, which was mediated by NMDA type of glutamate receptor. Furthermore, enhanced excitatory input inhibited neuronal excitability. Taken together, our results suggest that excitatory neurotransmission affects neuronal excitability via the regulation of the K+ channel membrane translocation.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1732
Appears in Collections:神经所(总)_期刊论文
神经信号转导研究组_期刊论文

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Shen, Bin; Zhou, Kechun; Yang, Shenglian; Xu, Tianle; Wang, Yizheng.The Kv4.2 mediates excitatory activity-dependent regulation of neuronal excitability in rat cortical neurons,JOURNAL OF NEUROCHEMISTRY,2008,105(3):773-783
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