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Title: Role of IGF signaling in olfactory sensory map formation and axon guidance
Author: Scolnick, Jonathan A. ; Cui, Kai ; Duggan, Cynthia D. ; Xuan, Shouhong ; Yuan, Xiao-Bing ; Efstratiadis, Argiris ; Ngai, John
Source: NEURON
Issued Date: 2008
Volume: 57, Issue:6, Pages:847-857
Keyword: GROWTH CONE GUIDANCE ; RECEPTOR GENE-EXPRESSION ; FACTOR-II GENE ; ODORANT RECEPTOR ; TOPOGRAPHIC MAP ; MICE DEFICIENT ; MOTOR-NEURONS ; BULB ; SYSTEM ; GLOMERULI
Subject: Neurosciences & Neurology
Corresponding Author: Ngai, J (reprint author), Univ Calif Berkeley, Helen Wills Neurosci Inst, Funct Genom Lab, Dept Mol & Cell Biol, Berkeley, CA 94720 USA,jngai@socrates.berkeley.edu
English Abstract: Olfactory neurons project their axons to spatially invariant glomeruli in the olfactory bulb, forming an ordered pattern of innervation comprising the olfactory sensory map. A mirror symmetry exists within this map, such that neurons expressing a given receptor typically project to one glomerulus on the medial face and one glomerulus on the lateral face of the bulb. The mechanisms underlying an olfactory neuron's choice to project medially versus laterally remain largely unknown, however. Here we demonstrate that insulin-like growth factor (IGF) signaling is required for sensory innervation of the lateral olfactory bulb. Mutations that eliminate IGF signaling cause axons destined for targets in the lateral bulb to shift to ectopic sites on the ventral-medial surface. Using primary cultures of olfactory and cerebellar neurons, we further show that IGF is a chemoattractant for axon growth cones. Together these observations reveal a role of IGF signaling in sensory map formation and axon guidance.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1735
Appears in Collections:神经所(总)_期刊论文

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Scolnick, Jonathan A.; Cui, Kai; Duggan, Cynthia D.; Xuan, Shouhong; Yuan, Xiao-Bing; Efstratiadis, Argiris; Ngai, John.Role of IGF signaling in olfactory sensory map formation and axon guidance,NEURON,2008,57(6):847-857
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