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Title: Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition
Author: Zhang, Long-Hua ; Gong, Neng ; Fei, Da ; Xu, Lin ; Xu, Tian-Le
Source: NEUROPSYCHOPHARMACOLOGY
Issued Date: 2008
Volume: 33, Issue:3, Pages:701-711
Keyword: glycine receptor ; glycine transporter ; hippocampus ; EPSP-spike coupling ; tonic inhibition ; glia ; TRANSPORTER SUBTYPE 1B ; SYNAPTIC-TRANSMISSION ; IN-VITRO ; ARACHIDONIC-ACID ; CROSS-INHIBITION ; NERVOUS-SYSTEM ; CA1 NEURONS ; SPINAL-CORD ; D-SERINE ; RAT
Subject: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
Corresponding Author: Xu, TL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn
English Abstract: Functional glycine receptors (GlyRs) are enriched in the hippocampus, but their role in hippocampal function remains unclear. Since the concentration of ambient glycine is determined by the presence of powerful glycine transporter (GlyT), we blocked the reuptake of glycine in hippocampal slices to examine the role of GlyRs. Antagonists of GlyT type 1 (GlyT1) but not that of GlyT type 2 (GlyT2) induced excitatory postsynaptic potential (EPSP)-spike depression, which was reversed by the specific GlyR antagonist strychnine. Moreover, endogenously elevating the glycine concentration with the GlyT1 antagonists facilitated NMDA receptor-dependent longterm potentiation induction, and elicited a strychnine-sensitive chloride current. In addition, impairment of glial function with fluoroacetate blocked the effect of GlyT1 antagonists on the EPSP-spike curve. Furthermore, pretreatment with sarcosine was effective in controlling pentylenetetrazol-induced seizures. These results indicate an essential role of GlyTs in fine-tuning tonic activation of GlyRs and suggest a potential role of GlyR-dependent EPSP-spike depression in hippocampal network stability.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1741
Appears in Collections:神经所(总)_期刊论文

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Zhang, Long-Hua; Gong, Neng; Fei, Da; Xu, Lin; Xu, Tian-Le.Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition,NEUROPSYCHOPHARMACOLOGY,2008,33(3):701-711
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