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Title: Effect of polybrominated diphenyl ether on development of cultured hippocampal neuron
Author: Liao ChunYang ; Duan ShuMin ; Jiang GuiBin
Source: SCIENCE IN CHINA SERIES B-CHEMISTRY
Issued Date: 2008
Volume: 51, Issue:1, Pages:62-68
Keyword: polybrominated diphenyl ether (PBDE) ; neuron ; neurite ; synapse ; development inhibition ; BROMINATED FLAME RETARDANTS ; GROWTH CONE ; EXPOSURE ; MICE ; ENVIRONMENT ; PBDES
Subject: Chemistry
Corresponding Author: Jiang, G (reprint author), Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China,gbjiang@rcees.ac.cn
English Abstract: Polybrominated diphenyl ether (PBDE) is a persistently environmental pollutant ubiquitously found in wildlife and humans. Although concern on PBDE's toxic effects is steadily increasing, its action on the central nervous system (CNS) remains largely unknown. To address this issue, the present study examined the development inhibition of PBDE in neurons. The primary cultured hippocampal neurons of rat were exposed to the commercial decabromodiphenyl ether (deca-BDE), and the neurite length, bifurcation, and synapse formation and maturation were evaluated, based on the confocal microscope imaging. The results showed that the development inhibition in neurons occurred at 15 mu mol/L, indicating that PBDE is a potent neurotoxicant and it might obviously inhibit the development of cultured neurons.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1745
Appears in Collections:神经所(总)_期刊论文

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Liao ChunYang; Duan ShuMin; Jiang GuiBin.Effect of polybrominated diphenyl ether on development of cultured hippocampal neuron,SCIENCE IN CHINA SERIES B-CHEMISTRY,2008,51(1):62-68
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