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Title: Spike-timing-dependent plasticity of neocortical excitatory Synapses on inhibitory Interneurons depends on target cell type
Author: Lu, Jiang-teng ; Li, Cheng-yu ; Zhao, Jian-Ping ; null(蒲慕明) ; Zhang, Xiao-hui
Source: JOURNAL OF NEUROSCIENCE
Issued Date: 2007
Volume: 27, Issue:36, Pages:9711-9720
Keyword: synaptic plasticity ; spike-timing-dependent plasticity ; STDP ; excitatory synapse ; inhibitory interneuron ; target-cell specificity ; somatosensory cortex ; LONG-TERM POTENTIATION ; PAIRED-PULSE DEPRESSION ; 2 COINCIDENCE DETECTORS ; SYNAPTIC PLASTICITY ; HIPPOCAMPAL INTERNEURONS ; CORTICAL DEVELOPMENT ; GLUTAMATE RECEPTORS ; PYRAMIDAL CELLS ; BARREL CORTEX ; RAT NEOCORTEX
Subject: Neurosciences & Neurology
Corresponding Author: Zhang, XH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,mpoo@berkeley.edu ; xhzhang@ion.ac.cn
English Abstract: Repetitive correlated spiking can induce long-term potentiation ( LTP) and long-term depression ( LTD) of many excitatory synapses on glutamatergic neurons, in a manner that depends on the timing of presynaptic and postsynaptic spiking. However, it is mostly unknown whether and how such spike-timing-dependent plasticity ( STDP) operates at neocortical excitatory synapses on inhibitory interneurons, which have diverse physiological and morphological characteristics. In this study, we found that these synapses exhibit target-cell-dependent STDP. In layer 2/3 of the somatosensory cortex, the pyramidal cell ( PC) forms divergent synapses on fast spiking ( FS) and low-threshold spiking ( LTS) interneurons that exhibit short-term synaptic depression and facilitation in response to high-frequency stimulation, respectively. At PC-LTS synapses, repetitive correlated spiking induced LTP or LTD, depending on the timing of presynaptic and postsynaptic spiking. However, regardless of the timing and frequency of spiking, correlated activity induced only LTD at PC-FS synapses. This target-cell-specific STDP was not caused by the difference in the short-term plasticity between these two types of synapses. Activation of postsynaptic NMDA subtype of glutamate receptors ( NMDARs) was required for LTP induction at PC-LTS synapses, whereas activation of metabotropic glutamate receptors was required for LTD induction at both PC-LTS and PC-FS synapses. Additional analysis of synaptic currents suggests that LTP and LTD of PC-LTS synapses, but not LTD of PC-FS synapses, involves presynaptic modifications. Such dependence of both the induction and expression of STDP on the type of postsynaptic interneurons may contribute to differential processing and storage of information in cortical local circuits.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1752
Appears in Collections:神经所(总)_期刊论文
神经可塑性研究组_期刊论文
神经元功能环路研究组_期刊论文

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Recommended Citation:
Lu, Jiang-teng; Li, Cheng-yu; Zhao, Jian-Ping; Poo, Mu-ming; Zhang, Xiao-hui.Spike-timing-dependent plasticity of neocortical excitatory Synapses on inhibitory Interneurons depends on target cell type,JOURNAL OF NEUROSCIENCE,2007,27(36):9711-9720
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