中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Selective control of cortical axonal spikes by a slowly inactivating K(+) current
Author: null(舒友生) ; Yu, Yuguo ; Yang, Jing ; McCormick, David A.
Source: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Issued Date: 2007
Volume: 104, Issue:27, Pages:11453-11458
Keyword: axon ; cortex ; plasticity ; synaptic transmission ; NEOCORTICAL PYRAMIDAL NEURONS ; ACTION-POTENTIAL INITIATION ; GATED POTASSIUM CHANNELS ; HIPPOCAMPAL-NEURONS ; ALPHA-SUBUNIT ; ION CHANNELS ; TRANSMITTER RELEASE ; CEREBELLAR BASKET ; XENOPUS OOCYTES ; BETA-SUBUNIT
Subject: Science & Technology - Other Topics
Corresponding Author: McCormick, DA (reprint author), Yale Univ, Sch Med, Kavli Inst Neurosci, Dept Neurobiol, 333 Cedar St, New Haven, CT 06510 USA,david.mccormick@yale.edu
English Abstract: Neurons are flexible electrophysiological entities in which the distribution and properties of ionic channels control their behaviors. Through simultaneous somatic and axonal whole-cell recording of layer 5 pyramidal cells, we demonstrate a remarkable differential expression of slowly inactivating K(+) currents. Depolarizing the axon, but not the soma, rapidly activated a low-threshold, slowly inactivating, outward current that was potently blocked by low doses of 4-aminopyridine, a-dendrotoxin, and rTityustoxin-K alpha. Block of this slowly inactivating current caused a large increase in spike duration in the axon but only a small increase in the soma and could result in distal axons generating repetitive discharge in response to local current injection. Importantly, this current was also responsible for slow changes in the axonal spike duration that are observed after somatic membrane potential change. These data indicate that low-threshold, slowly inactivating K+ currents, containing Kv1.2 alpha subunits, play a key role in the flexible properties of intracortical axons and may contribute significantly to intracortical processing.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1759
Appears in Collections:神经所(总)_期刊论文
神经网络功能研究组_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Shu-2007-Selective control of.pdf(2996KB)----开放获取View Download

Recommended Citation:
Shu, Yousheng; Yu, Yuguo; Yang, Jing; McCormick, David A..Selective control of cortical axonal spikes by a slowly inactivating K(+) current,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2007,104(27):11453-11458
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Shu, Yousheng]'s Articles
[Yu, Yuguo]'s Articles
[Yang, Jing]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shu, Yousheng]‘s Articles
[Yu, Yuguo]‘s Articles
[Yang, Jing]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Shu-2007-Selective control of.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!