中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Study of tauopathies by comparing Drosophila and human tau in Drosophila
Author: Chen, Xinping ; Li, Yan ; Huang, Junbo ; Cao, Dawei ; Yang, Guoying ; Liu, Weijie ; Lu, Huimin ; Guo, Aike
Source: CELL AND TISSUE RESEARCH
Issued Date: 2007
Volume: 329, Issue:1, Pages:169-178
Keyword: tau ; tauopathy ; comparison ; conservation ; Drosophila ; PAIRED HELICAL FILAMENTS ; PROTEIN-TAU ; TRANSGENIC MICE ; FRONTOTEMPORAL DEMENTIA ; ALZHEIMERS-DISEASE ; NERVOUS-SYSTEM ; NEURODEGENERATION ; PHOSPHORYLATION ; GENE ; AXONOPATHY
Subject: Cell Biology
Corresponding Author: Guo, AK (reprint author), Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, Beijing 100101, Peoples R China,akguo@ion.ac.cn
English Abstract: The microtubule-binding protein tau has been investigated for its contribution to various neurodegenerative disorders. However, the findings from transgenic studies, using the same tau transgene, vary widely among different laboratories. Here, we have investigated the potential mechanisms underlying tauopathies by comparing Drosophila (d-tau) and human (h-tau) tau in a Drosophila model. Overexpression of a single copy of either tau isoform in the retina results in a similar rough eye phenotype. However, co-expression of Par-1 with d-tau leads to lethality, whereas co-expression of Par-1 with h-tau has little effect on the rough eye phenotype. We have found analogous results by comparing larval proteomes. Through genetic screening and proteomic analysis, we have identified some important potential modifiers and tau-associated proteins. These results suggest that the two tau genes differ significantly. This comparison between species-specific isoforms may help to clarify whether the homologous tau genes are conserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1760
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Chen-2007-Study of tauopathies.pdf(560KB)----开放获取View Download

Recommended Citation:
Chen, Xinping; Li, Yan; Huang, Junbo; Cao, Dawei; Yang, Guoying; Liu, Weijie; Lu, Huimin; Guo, Aike.Study of tauopathies by comparing Drosophila and human tau in Drosophila,CELL AND TISSUE RESEARCH,2007,329(1):169-178
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chen, Xinping]'s Articles
[Li, Yan]'s Articles
[Huang, Junbo]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chen, Xinping]‘s Articles
[Li, Yan]‘s Articles
[Huang, Junbo]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Chen-2007-Study of tauopathies.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!