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Title: Transducer of regulated CREB and late phase long-term synaptic potentiation
Author: Wu, Hao ; Zhou, Yang ; null(熊志奇)
Source: FEBS JOURNAL
Issued Date: 2007
Volume: 274, Issue:13, Pages:3218-3223
Keyword: CREB ; hippocampus ; LTP ; TORCs ; ELEMENT-BINDING PROTEIN ; SENSITIVE COINCIDENCE DETECTOR ; MEDIATED GENE-EXPRESSION ; COACTIVATOR TORC2 ; TRANSCRIPTION FACTORS ; MEMORY ; HIPPOCAMPUS ; INDUCTION ; MECHANISM ; CALCIUM
Subject: Biochemistry & Molecular Biology
Corresponding Author: Xiong, ZQ (reprint author), Chinese Acad Sci, Lab Neurobiol Dis, Inst Neurosci, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,xiongzhiqi@ion.ac.cn
English Abstract: In the central nervous system, long-term adaptive responses to changes in the environment, such as the processes involved in learning and memory, require the conversion of extracellular stimuli into intracellular signals. Many of these signals involve the induction of gene expression. The late, transcription- and translation-dependent phase of long-term synaptic potentiation (L-LTP) is an attractive cellular model for long-lasting memory formation. The transcription factor cAMP response element-binding protein (CREB) plays an essential role in the maintenance of L-LTP. However, how synaptic signals propagate to the nucleus to initiate CREB-target gene expression is unclear. Recent studies indicate that the CREB transducer of regulated CREB activity 1 coactivator undergoes neuronal activity-dependent translocation from the cytoplasm to the nucleus, a process required for CRE-dependent gene expression and the maintenance of L-LTP in the hippocampus.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1761
Appears in Collections:神经所(总)_期刊论文
疾病神经生物学研究组_期刊论文

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Wu, Hao; Zhou, Yang; Xiong, Zhi-Qi.Transducer of regulated CREB and late phase long-term synaptic potentiation,FEBS JOURNAL,2007,274(13):3218-3223
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