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Title: Dishevelled promotes axon differentiation by regulating atypical protein kinase C
Author: Zhang, Xian ; Zhu, Ji ; Yang, Guo-Ying ; Wang, Qing-Jie ; Qian, Lei ; Chen, Yan-Min ; Chen, Fei ; Tao, Yu ; Hu, Han-Song ; Wang, Tong ; null(罗振革)
Source: NATURE CELL BIOLOGY
Issued Date: 2007
Volume: 9, Issue:7, Pages:743-U27
Keyword: HIPPOCAMPAL NEURONAL POLARITY ; WNT SIGNALING PATHWAY ; CELL-POLARITY ; ESTABLISHMENT ; GSK-3-BETA ; PAR-1 ; GUIDANCE ; ELEGANS ; COMPLEX ; CDC42
Subject: Cell Biology
Corresponding Author: Luo, ZG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,zgluo@ion.ac.cn
English Abstract: The atypical protein kinase C (aPKC) in complex with PAR3 and PAR6 is required for axon-dendrite differentiation, but the upstream factors responsible for regulating its activity are largely unknown. Here, we report that in cultured hippocampal neurons aPKC is directly regulated by Dishevelled (Dvl), an immediate downstream effector of Wnt. We found that downregulation of Dvl abrogated axon differentiation, whereas Dvl overexpression resulted in multiple axon formation. Interestingly, Dvl was associated with aPKC and this interaction resulted in aPKC stabilization and activation. Furthermore, the multiple axon formation resulting from Dvl overexpression was attenuated by expressing a dominant-negative aPKC in these neurons and overexpression of aPKC prevented the loss of axon caused by Dvl downregulation. Finally, Wnt5a, a noncanonical Wnt, activated aPKC and promoted axon differentiation. The Wnt5a effect on axon differentiation was attenuated by downregulating Dvl or inhibiting aPKC. Thus, Dvl-aPKC interaction can promote axon differentiation mediated by the PAR3-PAR6-aPKC complex.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1762
Appears in Collections:神经所(总)_期刊论文
突触信号研究组_期刊论文

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Zhang, Xian; Zhu, Ji; Yang, Guo-Ying; Wang, Qing-Jie; Qian, Lei; Chen, Yan-Min; Chen, Fei; Tao, Yu; Hu, Han-Song; Wang, Tong; Luo, Zhen-Ge.Dishevelled promotes axon differentiation by regulating atypical protein kinase C,NATURE CELL BIOLOGY,2007,9(7):743-U27
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