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Title: Role of the integrin-linked kinase (ILK) in detennining neuronal polarity
Author: Guo, Wei ; Jiang, Hui ; Gray, Virginia ; Dedhar, Shoukat ; Rao, Yi
Source: DEVELOPMENTAL BIOLOGY
Issued Date: 2007
Volume: 306, Issue:2, Pages:457-468
Keyword: integrin-linked kinase ; neuronal polarity ; glycogen synthase kinase-3 beta ; Akt ; PI3K ; axon determination ; GLYCOGEN-SYNTHASE KINASE ; DISPERSED CELL-CULTURE ; ONLY PROTEIN PINCH ; HIPPOCAMPAL-NEURONS ; REGULATES PHOSPHORYLATION ; THERAPEUTIC TARGET ; SIGNALING PATHWAYS ; B/AKT ACTIVATION ; BINDING-PROTEIN ; AXON FORMATION
Subject: Developmental Biology
Corresponding Author: Rao, Y (reprint author), Northwestern Univ, Feinberg Sch Med, Dept Neurol, 303 E Chicago Ave,Ward 10-185, Chicago, IL 60611 USA,y-rao@northwestern.edu
English Abstract: The establishment of axon-dendrite polarity in mammalian neurons has recently been shown to involve the kinases Akt and GSK-3 beta. Here we report the function of the integrin-linked kinase (ILK) in neuronal polarization. ILK distribution is differential: with more of it present in the axonal tips than that in the dendritic tips of a polarized neuron. Inactivation of ILK by chemical inhibitors, a kinase-inactive mutant or siRNAs inhibited axon formation, whereas a kinase hyperactive ILK mutant induced the formation of multiple axons. Biochemical studies indicate that ILK is upstream of Akt and GSK-3 beta. Manipulations of multiple intracellular components indicate that ILK is functionally upstream of Akt and GSK-3 beta but downstream of PI3K in neuronal polarity. These results reveal a key role of ILK in the formation of neuronal polarity and suggest a signaling pathway important for neuronal polarity. (C) 2007 Elsevier Inc. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1767
Appears in Collections:神经所(总)_期刊论文

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Guo, Wei; Jiang, Hui; Gray, Virginia; Dedhar, Shoukat; Rao, Yi.Role of the integrin-linked kinase (ILK) in detennining neuronal polarity,DEVELOPMENTAL BIOLOGY,2007,306(2):457-468
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