中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Development of the mesencephalic trigeminal nucleus requires a paired homeodomain transcription factor, Drg11
Author: Wang, Cheng-Zhong ; Shi, Ming ; Yang, Ling-Ling ; Yang, Rong-Qiang ; null(罗振革) ; Jacquin, Mark F. ; Chen, Zhou-Feng ; Ding, Yu-Qiang
Source: MOLECULAR AND CELLULAR NEUROSCIENCE
Issued Date: 2007
Volume: 35, Issue:2, Pages:368-376
Keyword: Drg11 ; transcription factor ; mesencephalic trigeminal nucleus ; development ; cell survival ; MASSETER MUSCLE ; NEURONS ; MOUSE ; RAT ; GANGLION ; INVIVO ; SYSTEM ; BRN-3A ; NERVE ; MICE
Subject: Neurosciences & Neurology
Corresponding Author: Ding, YQ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,dingyq@ion.ac.cn
English Abstract: The mesencephatic trigeminal nucleus (Me5) innervates muscle spindles and is responsible for receiving and transmitting proprioception from the oro-facial region. Molecular mechanisms underlying the development of the Me5 are poorly understood. Evidence is provided here that transcription factor Drg11 is required for Me5 development. Drg11 was expressed in the Me5 cells of the embryonic and early postnatal mouse brains, and the Me5 cells were absent in Drg11(-/-) mice at birth. The absence of the Me5 cells in Drg11(-/-) mice appeared to be caused by increased cell death in the Me5 during embryonic development. In postnatal Drg11(-/-) mice, Me5 cell innervation of masseter muscle spindles was undetectable, while robust trigeminal motoneuron innervation of masseter muscle fibers was detected. The postnatal body weight of Drg11(-/-) mice was notably less than that of wild-type mice, and this might result, in part, from disruption of the oro-facial proprioceptive afferent pathway. Taken together, our results demonstrate an essential role for Drg11 in the development of the Me5. (c) 2007 Elsevier Inc. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1769
Appears in Collections:神经所(总)_期刊论文
突触信号研究组_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
1-s2.0-S1044743107000826-main.pdf(5097KB)----开放获取View Download

Recommended Citation:
Wang, Cheng-Zhong; Shi, Ming; Yang, Ling-Ling; Yang, Rong-Qiang; Luo, Zhen-Ge; Jacquin, Mark F.; Chen, Zhou-Feng; Ding, Yu-Qiang.Development of the mesencephalic trigeminal nucleus requires a paired homeodomain transcription factor, Drg11,MOLECULAR AND CELLULAR NEUROSCIENCE,2007,35(2):368-376
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Cheng-Zhong]'s Articles
[Shi, Ming]'s Articles
[Yang, Ling-Ling]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Cheng-Zhong]‘s Articles
[Shi, Ming]‘s Articles
[Yang, Ling-Ling]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 1-s2.0-S1044743107000826-main.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!