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Title: TRPC channels promote cerebellar granule neuron survival
Author: Jia, Yichang ; Zhou, Jian ; Tai, Yilin ; null(王以政)
Source: NATURE NEUROSCIENCE
Issued Date: 2007
Volume: 10, Issue:5, Pages:559-567
Keyword: NERVE GROWTH CONES ; SIGNALING PATHWAY ; CELL-DEATH ; CREB PHOSPHORYLATION ; TRANSCRIPTION FACTOR ; NEUROTROPHIC FACTOR ; CALCIUM-CHANNEL ; GENE-EXPRESSION ; CATION CHANNELS ; KINASE PATHWAY
Subject: Neurosciences & Neurology
Corresponding Author: Wang, YZ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Key Lab Neurobiol,Lab Neural Signal Transduct, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn
English Abstract: Channels formed by the transient receptor potential (TRP) family of proteins have a variety of physiological functions. Here we report that two members of the TRP cation channel (TRPC) subfamily, TRPC3 and 6, protected cerebellar granule neurons ( CGNs) against serum deprivation - induced cell death in cultures and promoted CGN survival in rat brain. In CGN cultures, blocking TRPC channels or downregulating TRPC3 or 6 suppressed brain- derived neurotrophic factor ( BDNF) - mediated protection, BDNF-triggered intracellular Ca2+ elevation and BDNF-induced CREB activation. By contrast, overexpressing TRPC3 or 6 increased CREB-dependent reporter gene transcription and prevented apoptosis in the neurons deprived of serum, and this protection was blocked by the dominant negative form of CREB. Furthermore, downregulating TRPC3 or 6 induced CGN apoptosis in neonatal rat cerebellum, and this effect was rescued by overexpressing either TRPC3 or 6. Thus, our findings provide in vitro and in vivo evidence that TRPC channels are important in promoting neuronal survival.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1775
Appears in Collections:神经所(总)_期刊论文
神经信号转导研究组_期刊论文

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Jia, Yichang; Zhou, Jian; Tai, Yilin; Wang, Yizheng.TRPC channels promote cerebellar granule neuron survival,NATURE NEUROSCIENCE,2007,10(5):559-567
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