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Title: Identification of acid-sensing ion channels in adenoid cystic carcinomas
Author: Ye, Jin-Hai ; Gao, Jun ; Wu, Yu-Nong ; Hu, Yong-Jie ; Zhang, Chen-Ping ; Xu, Tian-Le(徐天乐)
Source: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Issued Date: 2007
Volume: 355, Issue:4, Pages:986-992
Keyword: acid-sensing ion channels ; adenoid cystic carcinomas ; patch clamp ; RT-PCR ; western blotting ; MUTATIONS CAUSING NEURODEGENERATION ; MAMMALIAN DEGENERIN MDEG ; GATED NA+ CHANNEL ; CELL-LINE ; CAENORHABDITIS-ELEGANS ; POTASSIUM CHANNEL ; H+ ; CALCIUM ; PH ; LYMPHOCYTES
Subject: Biochemistry & Molecular Biology ; Biophysics
Corresponding Author: Zhang, CP (reprint author), Shanghai Jiao Tong Univ, Dept Oral & Maxillofacial Surg, Sch Stomatol,Shanghai Res Inst Stomatol, Affiliated Peoples Hosp 9, Shanghai 200011, Peoples R China,yjh98001@sjtu.edu.cn
English Abstract: Tissue acidosis is an important feature of tumor. The response of adenoid cystic carcinoma (ACC) cells to acidic solution was studied using whole-cell patch-clamp recording in the current study. An inward, amiloride-sensitive Na+ current was identified in cultured ACC2 cells while not in normal human salivary gland epithelial cells. Electrophysiological and pharmacological properties of the currents suggest that heteromeric acid-sensing ion channels (ASICs) containing 2a and 3 may be responsible for the proton-induced currents in the majority of ACC-2 cells. Consistent with it, analyses of RT-PCR and Western blotting demonstrated the presences of ASIC2a and 3 in ACC-2 cells. Furthermore, we observed the enhanced expression of ASIC2a and 3 in the sample of ACC tissues. These results indicate that the functional expression of ASICs is characteristic feature of ACC cells. (c) 2007 Elsevier Inc. All rights reserved.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1776
Appears in Collections:神经所(总)_期刊论文

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Ye, Jin-Hai; Gao, Jun; Wu, Yu-Nong; Hu, Yong-Jie; Zhang, Chen-Ping; Xu, Tian-Le.Identification of acid-sensing ion channels in adenoid cystic carcinomas,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,355(4):986-992
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