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Title: Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by Slit-2
Author: Guan, Chen-bing ; Xu, Hua-tai ; Jin, Ming ; Yuan, Xiao-bing ; null(蒲慕明)
Source: CELL
Issued Date: 2007
Volume: 129, Issue:2, Pages:385-395
Keyword: RHO-FAMILY GTPASES ; LEECH RETZIUS NEURONS ; NERVE GROWTH ; AXON GUIDANCE ; ENDOPLASMIC-RETICULUM ; DIRECTIONAL GUIDANCE ; REGULATED FORMATION ; TARGET CONTACT ; IN-VIVO ; CALCIUM
Subject: Biochemistry & Molecular Biology ; Cell Biology
Corresponding Author: Poo, MM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,yuanxb@ion.ac.cn ; mpoo@berkeley.edu
English Abstract: Neuronal migration and growth-cone extension are both guided by extracellular factors in the developing brain, but whether these two forms of guidance are mechanistically linked is unclear. Application of a Slit-2 gradient in front of the leading process of cultured cerebellar granule cells led to the collapse of the growth cone and the reversal of neuronal migration, an event preceded by a propagating Ca2+ wave from the growth cone to the soma. The Ca2+ wave was required for the Slit-2 effect and was sufficient by itself to induce the reversal of migration. The Slit-2-induced reversal of migration required active RhoA, which was accumulated at the front of the migrating neuron, and this polarized RhoA distribution was reversed during the migration reversal induced by either the Slit-2 gradient or the Ca (2+) wave. Thus, longrange Ca (2+) signaling coordinates the Slit-2induced changes in motility at two distant parts of migrating neurons by regulating RhoA distribution.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1777
Appears in Collections:神经所(总)_期刊论文
神经可塑性研究组_期刊论文

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Guan, Chen-bing; Xu, Hua-tai; Jin, Ming; Yuan, Xiao-bing; Poo, Mu-ming.Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by Slit-2,CELL,2007,129(2):385-395
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