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Title: beta-catenin regulates acetylcholine receptor clustering in muscle cells through interaction with rapsyn
Author: Zhang, Bin ; Luo, Shiwen ; Dong, Xian-Ping ; Zhang, Xian ; Liu, Chunming ; Luo, Zhenge ; Xiong, Wen-Cheng ; Mei, Lin
Source: JOURNAL OF NEUROSCIENCE
Issued Date: 2007
Volume: 27, Issue:15, Pages:3968-3973
Keyword: beta-catenin ; rapsyn ; interaction ; AChR ; cluster ; alpha-catenin ; NEUROMUSCULAR-JUNCTION ; ALPHA-CATENIN ; PROTEINS ; ACTIN ; AGRIN ; MUSK ; MORPHOGENESIS ; DICKKOPF-1 ; SYNAPSES ; FAMILY
Subject: Neurosciences & Neurology
Corresponding Author: Mei, L (reprint author), Med Coll Georgia, Inst Mol Med & Genet, Program Dev Neurobiol, Augusta, GA 30912 USA,lmei@mcg.edu
English Abstract: Agrin is believed to be a factor used by motoneurons to direct acetylcholine receptor (AChR) clustering at the neuromuscular junction. However, exactly how agrin mediates this effect remains unclear. Here we demonstrate that the beta-catenin interacts with rapsyn, a molecule key for AChR clustering. Agrin stimulation increases the association of beta-catenin with surface AChRs. Suppression of beta-catenin expression inhibited agrin-induced AChR clustering, suggesting a necessary role of beta-catenin in this event. The beta-catenin action did not appear to require the function of T-cell factors (TCFs), suggesting a mechanism independent of TCF-mediated transcription. In contrast, prevention of beta-catenin from interacting with beta-catenin attenuated agrin-induced AChR clustering. These results suggest that beta-catenin may serve as a link between AChRs and beta-catenin-associated cytoskeleton, revealing a novel function of beta-catenin in synaptogenesis.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1779
Appears in Collections:神经所(总)_期刊论文

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Zhang, Bin; Luo, Shiwen; Dong, Xian-Ping; Zhang, Xian; Liu, Chunming; Luo, Zhenge; Xiong, Wen-Cheng; Mei, Lin.beta-catenin regulates acetylcholine receptor clustering in muscle cells through interaction with rapsyn,JOURNAL OF NEUROSCIENCE,2007,27(15):3968-3973
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