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Title: Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation
Author: Zhang, Xiaochang ; Xu, Rener ; Zhu, Binggen ; Yang, Xiujuan ; Ding, Xu ; Duan, Shumin ; Xu, Tian ; Zhuang, Yuan ; Han, Min
Source: DEVELOPMENT
Issued Date: 2007
Volume: 134, Issue:5, Pages:901-908
Keyword: synaptic nuclei ; neuromuscular junction ; neonatal lethality ; nuclear envelope ; KASH ; SUN domain ; nesprin ; ANC-1 ; MSP-300 ; mouse ; NEMATODE CAENORHABDITIS-ELEGANS ; NUCLEAR-MEMBRANE PROTEIN ; NEUROMUSCULAR-JUNCTION ; ACTIN CYTOSKELETON ; MUSCLE-FIBERS ; IN-VIVO ; DROSOPHILA ; ENVELOPE ; KLARSICHT ; GENE
Subject: Developmental Biology
Corresponding Author: Xu, RN (reprint author), Fudan Univ, Sch Life Sci, Inst Dev Biol & Mol Med, Shanghai 200433, Peoples R China,rener_xu@fudan.edu.cn
English Abstract: Proper nuclear positioning is important to cell function in many biological processes during animal development. In certain cells, the KASH-domain-containing proteins have been shown to be associated with the nuclear envelope, and to be involved in both nuclear anchorage and migration. We investigated the mechanism and function of nuclear anchorage in skeletal muscle cells by generating mice with single and double-disruption of the KASH-domain-containing genes Syne1 (also known as Syne-1) and Syne2 (also known as Syne-2). We showed that the deletion of the KASH domain of Syne-1 abolished the formation of clusters of synaptic nuclei and disrupted the organization of non-synaptic nuclei in skeletal muscle. Further analysis indicated that the loss of synaptic nuclei in Syne-1 KASH-knockout mice significantly affected the innervation sites and caused longer motor nerve branches. Although disruption of neither Syne-1 nor Syne-2 affected viability or fertility, Syne-1; Syne-2 double-knockout mice died of respiratory failure within 20 minutes of birth. These results suggest that the KASH-domain-containing proteins Syne-1 and Syne-2 play crucial roles in anchoring both synaptic and non-synaptic myonuclei that are important for proper motor neuron innervation and respiration.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1784
Appears in Collections:神经所(总)_期刊论文

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Zhang, Xiaochang; Xu, Rener; Zhu, Binggen; Yang, Xiujuan; Ding, Xu; Duan, Shumin; Xu, Tian; Zhuang, Yuan; Han, Min.Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation,DEVELOPMENT,2007,134(5):901-908
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