中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Persistent enhancement of neuron-glia signaling mediated by increased extracellular K+ accompanying long-term synaptic potentiation
Author: Ge, Woo-Ping ; Duan, Shumin
Source: JOURNAL OF NEUROPHYSIOLOGY
Issued Date: 2007
Volume: 97, Issue:3, Pages:2564-2569
Keyword: FUNCTIONAL SPECIALIZATION ; GLUTAMATE TRANSPORTERS ; HIPPOCAMPAL ASTROCYTES ; CEREBELLAR CULTURE ; D-SERINE ; CURRENTS ; EXPRESSION ; CELLS ; SYNAPSES ; RELEASE
Subject: Neurosciences & Neurology ; Physiology
Corresponding Author: Duan, SM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,shumin@ion.ac.cn
English Abstract: Persistent enhancement of neuron-glia signaling mediated by increased extracellular K+ accompanying long-term synaptic potentiation. J Neurophysiol 97: 2564-2569, 2007. First published October 11, 2006; doi:10.1152/jn. 00146.2006. Neuron-glia signaling is important for neural development and functions. This signaling may be regulated by neuronal activity and undergo modification similar to long-term potentiation (LTP) of neuronal synapses, a hallmark of neuronal plasticity. We found that tetanic stimulation of Schaffer collaterals (Sc) in the hippocampus that induced LTP in neurons also resulted in LTP-like persistent elevation of Sc-evoked slow depolarization in perisynaptic astrocytes. The elevated slow depolarization in astrocytes was abolished by NMDA receptor antagonist and K+ channel inhibitors, but not by Ca2+ chelator BAPTA loaded in the recorded astrocytes, suggesting involvement of an increased extracellular K+ accumulation accompanying LTP of neuronal synapses. The increased K+ accumulation and astrocyte depolarization after LTP induction may reduce the efficiency of glial glutamate transporters, which may contribute to the enhanced synaptic efficacy. The neuronal activity-induced persistent enhancement of neuron-glia signaling may thus have important physiological relevance.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1786
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Ge-2007-Persistent enhanceme.pdf(242KB)----开放获取View Download

Recommended Citation:
Ge, Woo-Ping; Duan, Shumin.Persistent enhancement of neuron-glia signaling mediated by increased extracellular K+ accompanying long-term synaptic potentiation,JOURNAL OF NEUROPHYSIOLOGY,2007,97(3):2564-2569
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ge, Woo-Ping]'s Articles
[Duan, Shumin]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ge, Woo-Ping]‘s Articles
[Duan, Shumin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Ge-2007-Persistent enhanceme.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!