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Title: Myosin X regulates netrin receptors and functions in axonal path-finding
Author: Zhu, Xiao-Juan ; Wang, Cheng-Zhong ; Dai, Peng-Gao ; Xie, Yi ; Song, Ning-Ning ; Liu, Yu ; Du, Quan-Sheng ; Mei, Lin ; Ding, Yu-Qiang ; Xiong, Wen-Cheng
Source: NATURE CELL BIOLOGY
Issued Date: 2007
Volume: 9, Issue:2, Pages:184-U79
Keyword: FOCAL ADHESION KINASE ; GROWTH CONE GUIDANCE ; COLORECTAL-CANCER ; PLECKSTRIN HOMOLOGY ; NEURITE OUTGROWTH ; DCC ; PROTEIN ; CELLS ; MOTOR ; SRC
Subject: Cell Biology
Corresponding Author: Ding, YQ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,dingyq@ion.ac.cn ; wxiong@mcg.edu
English Abstract: Netrins regulate axon path-finding during development, but the underlying mechanisms are not well understood. Here, we provide evidence for the involvement of the unconventional myosin X (Myo X) in netrin-1 function. We find that Myo X interacts with the netrin receptor deleted in colorectal cancer (DCC) and neogenin, a DCC-related protein. Expression of Myo X redistributes DCC to the cell periphery or to the tips of neurites, whereas its silencing prevents DCC distribution in neurites. Moreover, expression of DCC, but not neogenin, stimulates Myo X-mediated formation and elongation of filopodia, suggesting that Myo X function may be differentially regulated by DCC and neogenin. The involvement of Myo X in netrin-1 function was further supported by the effects of inhibiting Myo X function in neurons. Cortical explants derived from mouse embryos expressing a motor-less Myo X exhibit reduced neurite outgrowth in response to netrin-1 and chick commissural neurons expressing the motor-less Myo X, or in which Myo X is silenced using microRNA (miRNA), show impaired axon projection in vivo. Taken together, these results identify a novel role for Myo X in regulating netrin-1 function.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1788
Appears in Collections:神经所(总)_期刊论文

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Zhu, Xiao-Juan; Wang, Cheng-Zhong; Dai, Peng-Gao; Xie, Yi; Song, Ning-Ning; Liu, Yu; Du, Quan-Sheng; Mei, Lin; Ding, Yu-Qiang; Xiong, Wen-Cheng.Myosin X regulates netrin receptors and functions in axonal path-finding,NATURE CELL BIOLOGY,2007,9(2):184-U79
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