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Title: Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices
Author: Huang, H. -P. ; Wang, S. -R. ; Yao, W. ; Zhang, C. ; Zhou, Y. ; Chen, X. -W. ; Zhang, B. ; Xiong, W. ; Wang, L. -Y. ; Zheng, L. -H. ; Landry, M. ; Hokfelt, T. ; Xu, Z. -Q. D. ; Zhou, Z.
Source: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Issued Date: 2007
Volume: 104, Issue:4, Pages:1401-1406
Keyword: amperometry ; patch-clamp ; somatic release ; brain slice ; catecholamine ; ADRENAL CHROMAFFIN CELLS ; ENDOGENOUS NORADRENALINE RELEASE ; DUAL-PROBE MICRODIALYSIS ; GANGLION NEURONS ; STRUCTURAL ORGANIZATION ; NOREPINEPHRINE RELEASE ; AMPEROMETRIC DETECTION ; NORADRENERGIC NEURONS ; SEROTONERGIC NEURONS ; MEMBRANE-PROPERTIES
Subject: Science & Technology - Other Topics
Corresponding Author: Hokfelt, T (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,tomas.hokfelt@neuro.ki.se ; zzhou@pku.edu.cn
English Abstract: The locus coeruleus (LC) harbors a compact group of noradrenergic cell bodies projecting to virtually all parts of the central nervous system. By using combined measurements of amperometry and patch-clamp, quantal vesicle release of noradrenaline (NA) was detected as amperometric spikes, after depolarization of the LC neurons. After a pulse depolarization, the average latency of amperometric spikes was 1,870 ms, whereas the latency of glutamate-mediated excitatory postsynaptic currents was 1.6 ms. A substantial fraction of the depolarization-induced amperometric spikes originated from the somata. In contrast to glutamate-mediated excitatory postsynaptic currents, NA secretion was strongly modulated by the action potential frequency (0.5-50 Hz). Somatodendritic NA release from LC upon enhanced cell activity produced autoinhibition of firing and of NA release. We conclude that, in contrast to classic synaptic transmission, quantal NA release from LC somata is characterized by a number of distinct properties, including long latency and high sensitivity to action potential frequency.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1789
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Huang, H. -P.; Wang, S. -R.; Yao, W.; Zhang, C.; Zhou, Y.; Chen, X. -W.; Zhang, B.; Xiong, W.; Wang, L. -Y.; Zheng, L. -H.; Landry, M.; Hokfelt, T.; Xu, Z. -Q. D.; Zhou, Z..Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2007,104(4):1401-1406
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