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Title: Dynamic regulation of acid-sensing ion channels by extracellular and intracellular modulators
Author: Xu, Tian-Le(徐天乐) ; Xiong, Zhi-Gang
Source: CURRENT MEDICINAL CHEMISTRY
Issued Date: 2007
Volume: 14, Issue:16, Pages:1753-1763
Keyword: acid-sensing ion channel ; acidosis ; neuron ; modulation ; ROOT GANGLION NEURONS ; PROTON-GATED CHANNELS ; TARANTULA TOXIN PSALMOTOXIN-1 ; EXPERIMENTAL TISSUE ACIDOSIS ; EPITHELIAL SODIUM-CHANNEL ; MOUSE CORTICAL-NEURONS ; BRAIN NA+ CHANNEL ; PROTEIN-KINASE-C ; SENSORY NEURONS ; HIPPOCAMPAL-NEURONS
Subject: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
Corresponding Author: Xu, TL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn
English Abstract: Changes of extracellular pH values can have profound effects on neuronal function. For example, the low pH (also called acidosis) generated in brain ischemia causes acute neuronal injury. For years the receptors that detect pH variations surrounding neurons and their physiological/pathological importance remain uncertain, The recent finding that acidosis activates a distinct family of membrane ion channels, the acid-sensing ion channels (ASICs) in both peripheral and central neurons has dramatically changed the view of acidosis-associated signaling and provided a new strategy for therapeutic inventions. Although proton is the only known agonist for the activation of ASICs, a variety of extracellular and intracellular signaling molecules can modulate the activities of ASICs and have profound influence on the functions of these channels in both physiological and pathological processes. The goal of this article is therefore to provide a comprehensive review of the modulators of ASICs that adapt ASIC activity to changes of extracellular and intracellular environments.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1794
Appears in Collections:神经所(总)_期刊论文

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Xu, Tian-Le; Xiong, Zhi-Gang.Dynamic regulation of acid-sensing ion channels by extracellular and intracellular modulators,CURRENT MEDICINAL CHEMISTRY,2007,14(16):1753-1763
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