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Title: Requirement of TORC1 for Late-Phase Long-Term Potentiation in the Hippocampus
Author: Zhou, Yang ; Wu, Hao ; Li, Shuai ; Chen, Qian ; Cheng, Xue-Wen ; Zheng, Jing ; Takemori, Hiroshi ; null(熊志奇)
Source: PLOS ONE
Issued Date: 2006
Volume: 1, Issue:1, Pages:e16-e16
Subject: Life Sciences & Biomedicine - Other Topics
Corresponding Author: Xiong, ZQ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China,xiongzhiqi@ion.ac.cn
English Abstract: Late-phase long-term potentiation (L-LTP) and long-term memory depend on the transcription of mRNA of CRE-driven genes and synthesis of proteins. However, how synaptic signals propagate to the nucleus is unclear. Here we report that the CREB coactivator TORC1 (transducer of regulated CREB activity 1) undergoes neuronal activity-induced translocation from the cytoplasm to the nucleus, a process required for CRE-dependent gene expression and L-LTP. Overexpressing a dominant-negative form of TORC1 or down-regulating TORC1 expression prevented activity-dependent transcription of CREB target genes in cultured hippocampal neurons, while overexpressing a wild-type form of TORC1 facilitated basal and activity-induced transcription of CREB target genes. Furthermore, overexpressing the dominant-negative form of TORC1 suppressed the maintenance of L-LTP without affecting early-phase LTP, while overexpressing the wild-type form of TORC1 facilitated the induction of L-LTP in hippocampal slices. Our results indicate that TORC1 is essential for CRE-driven gene expression and maintenance of long-term synaptic potentiation.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1797
Appears in Collections:神经所(总)_期刊论文
疾病神经生物学研究组_期刊论文

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Recommended Citation:
Zhou, Yang; Wu, Hao; Li, Shuai; Chen, Qian; Cheng, Xue-Wen; Zheng, Jing; Takemori, Hiroshi; Xiong, Zhi-Qi.Requirement of TORC1 for Late-Phase Long-Term Potentiation in the Hippocampus,PLOS ONE,2006,1(1):e16-e16
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