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Title: The development and modulation of nociceptive circuitry
Author: Xu Zhang ; Lan Bao
Source: CURRENT OPINION IN NEUROBIOLOGY
Issued Date: 2006
Volume: 16, Issue:4, Pages:460-466
Keyword: DORSAL-ROOT GANGLION ; DELTA-OPIOID-RECEPTOR ; PRIMARY AFFERENT NEURONS ; PRIMARY SENSORY NEURONS ; NEUROPATHIC PAIN ; NEUROTROPHIC FACTOR ; SPINAL-CORD ; NERVE INJURY ; POSTSYNAPTIC LOCALIZATION ; GENE-EXPRESSION
Subject: Neurosciences & Neurology
Corresponding Author: Xu, Z (reprint author), Shanghai Inst Biol Sci, Key Lab Neurobiol, Inst Neurosci, Shanghai, Peoples R China,xu.zhang@ion.ac.cn
English Abstract: Nociceptive circuitry processes the signals evoked by activating specialized peripheral sensory receptors for pain perception. Recent studies show that the neuronal phenotypes in the dorsal root ganglia and spinal dorsal horn are determined by distinct sets of transcription factors during development. Anatomical analyses with genetic approaches demonstrate that each subset of nociceptive sensory neurons has topographically distinct circuits at both spinal and brain levels.. Moreover, the sensitivity of primary afferents can be. rapidly regulated not only by phosphorylation of receptors, ion channels and associated regulatory proteins but also by stimulus-induced cell surface expression of G-protein-coupled receptors. In chronic pain states the molecular characteristics of spinal nociceptive circuits are altered, enabling normal peripheral stimuli to induce pain hypersensitivity.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1808
Appears in Collections:神经所(总)_期刊论文

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Xu Zhang; Lan Bao.The development and modulation of nociceptive circuitry,CURRENT OPINION IN NEUROBIOLOGY,2006,16(4):460-466
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