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Title: Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity
Author: Yan, Dong ; Guo, Li ; null(王以政)
Source: JOURNAL OF CELL BIOLOGY
Issued Date: 2006
Volume: 174, Issue:3, Pages:415-424
Keyword: AKT/PROTEIN KINASE-B ; HIPPOCAMPAL-NEURONS ; PROTEIN-DEGRADATION ; NEURITE OUTGROWTH ; PI 3-KINASE ; CELLS ; GROWTH ; ESTABLISHMENT ; INHIBITION ; GSK-3-BETA
Subject: Cell Biology
Corresponding Author: Wang, YZ (reprint author), Chinese Acad Sci, Lab Neural Signal Transduct, Inst Neurosci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn
English Abstract: A symmetric distributions of activities of the protein kinases Akt and glycogen synthase kinase 3 beta (GSK-3 beta) are critical for the formation of neuronal polarity. However, the mechanisms underlying polarized regulation of this pathway remain unclear. In this study, we report that the instability of Akt regulated by the ubiquitin - proteasome system ( UPS) is required for neuron polarity. Preferential distribution in the axons was observed for Akt but not for its target GSK-3 beta. A photoactivatable GFP fused to Akt revealed the preferential instability of Akt in dendrites. Akt but not p110 or GSK-3 beta was ubiquitinated. Suppressing the UPS led to the symmetric distribution of Akt and the formation of multiple axons. These results indicate that local protein degradation mediated by the UPS is important in determining neuronal polarity.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1809
Appears in Collections:神经所(总)_期刊论文
神经信号转导研究组_期刊论文

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Yan, Dong; Guo, Li; Wang, Yizheng.Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity,JOURNAL OF CELL BIOLOGY,2006,174(3):415-424
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