中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: K+ regulates DNA binding of transcription factors to control gene expression related to neuronal apoptosis
Author: Yang, Qiaoyun ; Yan, Dong ; null(王以政)
Source: NEUROREPORT
Issued Date: 2006
Volume: 17, Issue:11, Pages:1199-1204
Keyword: cAMP-responsive element-binding protein ; DNA binding ; Forkhead ; neuron apoptosis ; p53 ; potassium ; SYMPATHETIC NEURONS ; CELL-SURVIVAL ; ACTIVATION ; POTASSIUM ; CREB ; DEATH ; MEDIATION ; PROTEINS ; KINASE
Subject: Neurosciences & Neurology
Corresponding Author: Wang, YZ (reprint author), Chinese Acad Sci, Inst Neurosci, SIBS, Lab Neural Signal Transduct,Grad Sch, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn
English Abstract: The loss of intracellular K+ promotes neuronal apoptosis. The mechanism by which K+ acts on apoptosis, however, remains largely unknown. Here we showed that K+ selectively affects DNA binding activity of transcriptional factors in vitro. Low K+ concentration ([K+]) promoted the DNA binding activity of p53 and Forkhead, proapoptotic transcriptional factors, whereas it inhibited that of cAMP-responsive element-binding protein, an anti-apoptotic transcriptional factor. In contrast, K+ did not affect the DNA binding activity of Ying Yang 1, CCAAT/enhancer binding protein and early growth response protein-L The expression of bax and bim, proapoptotic genes known to be regulated by pS3 and Forkhead, respectively, was enhanced in cortical neurons deprived of serum, condition known to cause K+ loss, whereas the expression of cfos, a cAMP-responsive element-binding protein target gene, was inhibited. Furthermore, blocking K+ channels suppressed the enhancement of bim mRNA level and the reduction of c-fos mRNA level induced by K+ loss, whereas it had no effect on the stimulation of Forkhead or cAMP-responsive element-binding protein induced by K+ loss. These results suggest that low intracellular [K+] selectively affects DNA binding activity of transcriptional factors to regulate gene expression related to neuronal apoptosis.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1810
Appears in Collections:神经所(总)_期刊论文
神经信号转导研究组_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
00001756-200607310-00024.pdf(296KB)----开放获取View Download

Recommended Citation:
Yang, Qiaoyun; Yan, Dong; Wang, Yizheng.K+ regulates DNA binding of transcription factors to control gene expression related to neuronal apoptosis,NEUROREPORT,2006,17(11):1199-1204
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Qiaoyun]'s Articles
[Yan, Dong]'s Articles
[Wang, Yizheng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Qiaoyun]‘s Articles
[Yan, Dong]‘s Articles
[Wang, Yizheng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 00001756-200607310-00024.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!