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Title: Lateral components in the cone terminals of the rabbit retina: Horizontal cell origin and glutamate receptor expression
Author: Deng, QD ; Wang, L ; Dong, W ; He, SG
Source: JOURNAL OF COMPARATIVE NEUROLOGY
Issued Date: 2006
Volume: 496, Issue:5, Pages:698-705
Keyword: triads ; gap junction ; Lucifer yellow ; neurobiotin ; EM ; intracellular injection ; MAMMALIAN RETINA ; PRIMATE RETINA ; CAT RETINA ; DOPAMINERGIC MODULATION ; KAINATE RECEPTORS ; AMPA RECEPTORS ; BIPOLAR CELLS ; GAP-JUNCTIONS ; SUBUNITS ; LOCALIZATION
Subject: Neurosciences & Neurology ; Zoology
Corresponding Author: He, SG (reprint author), Chinese Acad Sci, Inst Biophys, 15 Da Tun Rd, Beijing 100101, Peoples R China,shiganghe@moon.ibp.ac.cn
English Abstract: We examined the identities of horizontal cell (HQ lateral components in cone terminals and the expression of glutamate receptors on the tips of HC dendrites. We injected A-type horizontal cells (AHCs) with neurobiotin and demonstrated that neurobiotin labeled completely all AHCs within a patch of retina. We converted neurobiotin by using diaminobenzidine and considered labeled processes to be from AHCs and unlabeled processes to be from B-type horizontal cells (BHCs). Three possible combinations of HC dendrites could exist in cone pedicles: both lateral components originating from AHCs, both from BHCs, or one from an AHC and the other from a BHC. EM observations revealed that a majority of cone terminals contained about equal numbers of lateral components originating from each of the two types of HCs and that each of the three possible combinations was present in equal numbers. Localization of different types of glutamate receptors on HC dendritic tips showed that 55% of AHC dendritic tips expressed AMPA receptors and 30% expressed kainate receptors, whereas, in the case of BHCs, 22% of dendritic tips expressed AMPA receptors and 33% expressed kainate receptors. This study suggests that cone photoreceptors feed the light signal equally into networks of AHCs and BHCs and that differential expression of AMPA/ kainate receptors by different HCs could account for different functions.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1814
Appears in Collections:神经所(总)_期刊论文

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Deng, QD; Wang, L; Dong, W; He, SG.Lateral components in the cone terminals of the rabbit retina: Horizontal cell origin and glutamate receptor expression,JOURNAL OF COMPARATIVE NEUROLOGY,2006,496(5):698-705
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