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Title: Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats
Author: Zhang, LH ; Xu, L ; Xu, TL(徐天乐)
Source: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Issued Date: 2006
Volume: 344, Issue:3, Pages:721-726
Keyword: glycine receptor ; GABA(A) receptor ; hippocampus ; brain slice ; synaptic transmission ; short-term plasticity ; paired-pulse depression ; paired-pulse facilitation ; SYNAPTIC PLASTICITY ; DENTATE GYRUS ; CROSS-INHIBITION ; NEURONS ; SYNAPSES ; DEPRESSION ; MEMORY ; BRAIN ; GAIN
Subject: Biochemistry & Molecular Biology ; Biophysics
Corresponding Author: Xu, TL (reprint author), Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China,tlxu@ion.ac.cn
English Abstract: Functional glycine receptors (GlyRs) are enriched in the hippocampus, but their roles in synaptic transmission are unclear. In this study, we examined the effect of GlyR activation on paired-pulse stimulation of the whole-cell postsynaptic currents (PSCs) in the Schaffer-CA1 synapses in rat hippocampal slices. Bath application of glycine reduced the amplitude of PSCs, accompanied by all increase ill holding current and resting conductance. Moreover, glycine application increased the paired-pulse ratio (PPR) of PSCs significantly, all effect largely abolished by the GlyR specific antagonist strychnine. Interestingly, glycine application had no significant effect oil either the amplitude or the PPR of excitatory postsynaptic currents (EPSCs). Our findings suggest that GlyR activation regulates hippocampal short-term plasticity by altering GABAergic neurotransmission. (c) 2006 Elsevier Inc. All rights reserved.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1815
Appears in Collections:神经所(总)_期刊论文

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Zhang, LH; Xu, L; Xu, TL.Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,344(3):721-726
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