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Title: Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance
Author: null(张 旭) ; Bao, L ; Guan, JS
Source: TRENDS IN PHARMACOLOGICAL SCIENCES
Issued Date: 2006
Volume: 27, Issue:6, Pages:324-329
Keyword: PROTEIN-COUPLED RECEPTORS ; DORSAL-ROOT GANGLION ; VENTROLATERAL PERIAQUEDUCTAL GRAY ; CHRONIC MORPHINE TREATMENT ; RAT SPINAL-CORD ; KNOCK-OUT MICE ; NEUROPATHIC PAIN ; DOWN-REGULATION ; PHYSICAL-DEPENDENCE ; PERIPHERAL AXOTOMY
Subject: Pharmacology & Pharmacy
Corresponding Author: Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Key Lab Neurobiol, Shanghai 200031, Peoples R China,xu.zhang@ion.ac.cn
English Abstract: Changes in the number of receptors on the cell surface lead to modulations of physiological functions and pharmacological responses of neurons. Recent studies show that delta-opioid peptide (DOP) and mu-opioid peptide (MOP) receptors have distinct subcellular localizations in neurons. In nociceptive small neurons in the dorsal root ganglia, DOP receptors are sorted into neuropeptide-containing secretory vesicles, enabling the stimulus-induced cell surface expression of these receptors. MOP receptors are constitutively expressed on the cell surface. The physical interaction between DOP receptors and MOP receptors seems to be an important mechanism for the modulation of receptor functions. Experiments in animals show that MOP-receptor-mediated spinal analgesia is enhanced and morphine tolerance does not develop when DOP receptor functions are pharmacologically or genetically attenuated. Thus, the delivery and trafficking of DOP receptors are crucial processes that modulate opioid analgesia and tolerance.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1818
Appears in Collections:神经所(总)_期刊论文
感觉系统研究组_期刊论文

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Recommended Citation:
Zhang, X; Bao, L; Guan, JS.Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance,TRENDS IN PHARMACOLOGICAL SCIENCES,2006,27(6):324-329
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