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Title: Downregulation of KCC2 following LTP-contributes to EPSP-spike potentiation in rat hippocampus
Author: Wang, W ; Gong, N ; Xu, TL(徐天乐)
Source: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Issued Date: 2006
Volume: 343, Issue:4, Pages:1209-1215
Keyword: KCC2 ; LTP ; GABAergic inhibition ; NMDA receptor ; E-S potentiation ; LONG-TERM POTENTIATION ; GAMMA-AMINOBUTYRIC-ACID ; COTRANSPORTER KCC2 ; GABAERGIC SYNAPSES ; GABA(A) RECEPTORS ; PYRAMIDAL NEURONS ; CA1 NEURONS ; INDUCTION ; STIMULATION ; INHIBITION
Subject: Biochemistry & Molecular Biology ; Biophysics
Corresponding Author: Xu, TL (reprint author), Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China,tlxu@ion.ac.cn
English Abstract: GABAergic synaptic inhibition plays a critical role in regulating long-term potentiation (LTP) of glutamatergic synaptic transmission and circuit output. The K+-Cl- cotransporter 2 (KCC2) is an important factor in determining inhibitory GABAergic synaptic strength besides the contribution of GABA(A) receptor. Although much knowledge has been gained regarding activity-dependent downregulation of KCC2 in many pathological conditions, the potential change and contribution of KCC2 in UP expression is still unknown. In this study, we found that down regulation of KCC2 was accompanied with the occurrence of LTP but not that of long-term depression in hippocampal CA1 region. Meanwhile, KCC2 level in CA3/DG and adjacent cortex was stable in the process of LTP expression in Schaffer collateral synapses. Blockade of NMDA receptor with APV not only prevented LTP induction also abolished the reduction of KCC2. Furthermore, the inhibition of KCC2 function with furosemide directly induced EPSP-spike (E-S) potentiation, an important component of UP in hippocampus. The present data suggest a novel mechanism that LTP formation is accompanied by the downregulation of KCC2, which is underlying GABAergic strength and most likely contributes to the E-S potentiation following LTP. (c) 2006 Elsevier Inc. All rights reserved.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1823
Appears in Collections:神经所(总)_期刊论文

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Wang, W; Gong, N; Xu, TL.Downregulation of KCC2 following LTP-contributes to EPSP-spike potentiation in rat hippocampus,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,343(4):1209-1215
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