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Title: Sodium salicylate reduces inhibitory postsynaptic currents in-neurons of rat auditory cortex
Author: Wang, HT ; Luo, B ; Zhou, KQ ; Xu, TL(徐天乐) ; Chen, L
Source: HEARING RESEARCH
Issued Date: 2006
Volume: 215, Issue:40910, Pages:77-83
Keyword: sodium salicylate ; inhibitory postsynaptic current ; tinnitus ; auditory cortex ; whole-cell patch-clamp ; rat ; brain slice ; INFERIOR COLLICULUS ; ANIMAL-MODEL ; TINNITUS ; OTOTOXICITY ; PLASTICITY ; AI
Subject: Audiology & Speech-Language Pathology ; Neurosciences & Neurology ; Otorhinolaryngology
Corresponding Author: Chen, L (reprint author), Univ Sci & Technol China, Sch Life Sci, Auditory Res Lab, 443 Yellow Mt Rd, Hefei 230027, Peoples R China,linchen@ustc.edu.cn
English Abstract: Sodium salicylate (SS) is a medicine for anti-inflammation and for chronic pain relief with a side effect of tinnitus. To understand the cellular mechanisms of tinnitus induced by SS in the central auditory system, we examined effects of SS on evoked and miniature inhibitory postsynaptic currents (eIPSCs and mIPSCs) recorded from layer II/III pyramidal neurons of rat auditory cortex in a brain slice preparation with whole-cell patch-clamp techniques. Both eIPSCs and mIPSCs recorded from the auditory cortex could be completely blocked by bicuculline; a selective GABA(A) receptor antagonist. SS did not change the input resistance of neurons but was found to reversibly depress eIPSCs in a concentration-dependent manner. SS reduced eIPSCs to 82.3% of the control level at 0.5 mM (n = 7) and to 60.9% at 1.4 mM (n = 12). In addition, SS at 1.4 mM significantly reduced the amplitude of mIPSCs from 24.12 +/- 1.44 pA to 19.92 +/- 1.31 pA and reduced the frequency of mIPSCs from 1.34 +/- 0.23 Hz to 0.89 +/- 0.13 Hz (n = 6). Our results demonstrate that SS attenuates inhibitory postsynaptic currents in the auditory cortex, suggesting that the alteration of inhibitory neural circuits may be one of the cellular mechanisms for tinnitus induced by SS in the central auditory region. (c) 2006 Elsevier B.V. All rights reserved.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1828
Appears in Collections:神经所(总)_期刊论文

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Wang, HT; Luo, B; Zhou, KQ; Xu, TL; Chen, L.Sodium salicylate reduces inhibitory postsynaptic currents in-neurons of rat auditory cortex,HEARING RESEARCH,2006,215(40910):77-83
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