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Title: Low K+ promotes NF-kappa B/DNA binding in neuronal apoptosis induced by K+ loss
Author: Tao, YM ; Yan, D ; Yang, QY ; Zeng, R ; Wang, YZ
Source: MOLECULAR AND CELLULAR BIOLOGY
Issued Date: 2006
Volume: 26, Issue:3, Pages:1038-1050
Keyword: B TRANSCRIPTION FACTORS ; CYTOCHROME-C RELEASE ; BCL-X ; IN-VITRO ; LYMPHOCYTE-PROLIFERATION ; SENSORY NEURONS ; PROTEIN-KINASE ; MICE LACKING ; CELL-DEATH ; ACTIVATION
Subject: Biochemistry & Molecular Biology ; Cell Biology
Corresponding Author: Wang, YZ (reprint author), Chinese Acad Sci, SIBS, Inst Neurosci,Grad Sch, Lab Neural Signal Transduct, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn
English Abstract: Low intracellular K+ concentration ([K+](i)) promotes apoptosis and blocking K+ loss prevents apoptosis, but the mechanism of action of low [K+](i) remains unclear. Here, we show that low [K+](i) increases NF-kappa B transcriptional activity by enhancing its binding to the promoter of target genes without affecting its activation and nuclear translocation in cortical neurons deprived of serum. Low K+ concentration promotes NF-kappa B/DNA binding through direct effects on the interaction of NF-kappa B dimers with DNA. Up-regulation of proapoptotic protein Bcl-X-S and neuronal apoptosis induced by serum deprivation are blocked by inhibition and/or downregulation of NF-kappa B and by prevention of K+ loss. Thus, a direct action of K+ on NF-kappa B/DNA binding regulates gene transcription related to neuronal apoptosis.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1842
Appears in Collections:神经所(总)_期刊论文

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Tao, YM; Yan, D; Yang, QY; Zeng, R; Wang, YZ.Low K+ promotes NF-kappa B/DNA binding in neuronal apoptosis induced by K+ loss,MOLECULAR AND CELLULAR BIOLOGY,2006,26(3):1038-1050
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