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Title: Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo
Author: Dong, Zhifang ; Zhong, Weixia ; Tian, Meng ; Han, Huili ; Cao, Jun ; Xu, Tianle(徐天乐) ; Luo, Jianhong ; Xu, Lin
Source: HIPPOCAMPUS
Issued Date: 2006
Volume: 16, Issue:12, Pages:1017-1025
Keyword: opiate withdrawal ; long-term potentiation ; hippocampal CA1 ; stress ; LONG-TERM POTENTIATION ; SYNAPTIC PLASTICITY ; GLUCOCORTICOID-RECEPTORS ; MORPHINE-WITHDRAWAL ; POSSIBLE MECHANISMS ; RAT HIPPOCAMPUS ; SPATIAL MEMORY ; DRUG-ABUSE ; CA1 REGION ; DEPRESSION
Subject: Neurosciences & Neurology
Corresponding Author: Luo, JH (reprint author), Chinese Acad Sci, Kunming Inst Zool, Lab Anim Models & Human Dis Mechanisms, Kunming 650223, Yunnan, Peoples R China,luojianhong@zju.edu.cn
English Abstract: Stress impairs hippocampal long-term potentiation (LTP), but it is unknown whether the stress evoked by opiate withdrawal has the same effect. Here the authors report that opiate withdrawal for 4 days does not influence basal synaptic transmission, but results in a greatly increased LTP in hippocampal CA1 area in anesthetized rats. Elevated-platform stress enabled a large LTP in rats withdrawn for only 18 h, but the glucocorticoid receptor antagonist RU38486 (twice per day for 3 days) prevented the large LTP on 4 days withdrawal. Moreover, 4 days withdrawal enhanced the NMDAR-mediated EPSCs, in which the NR2A-containing NMDAR-mediated EPSC was increased but the NR2B-containing NMDAR-mediated EPSC was decreased. These results suggest that adaptive changes of the NMDAR and glucocorticoid receptor functions during 4 days of opiate withdrawal may enable stress to facilitate hippocampal LTP, potentially contributing to the opiate withdrawal experience-dependent modifications of hippocampal functions. (c) 2006 Wiley-Liss, Inc.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1844
Appears in Collections:神经所(总)_期刊论文

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Dong, Zhifang; Zhong, Weixia; Tian, Meng; Han, Huili; Cao, Jun; Xu, Tianle; Luo, Jianhong; Xu, Lin.Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo,HIPPOCAMPUS,2006,16(12):1017-1025
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