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Title: Differential expression of synaptoporin and synaptophysin in primary sensory neurons and up-regulation of synaptoporin after peripheral nerve injury
Author: Sun, T. ; Xiao, H-S. ; Zhou, P-B. ; Lu, Y-J. ; Bao, L. ; null(张 旭)
Source: NEUROSCIENCE
Issued Date: 2006
Volume: 141, Issue:3, Pages:1233-1245
Keyword: synaptic vesicle protein ; nociceptor ; dorsal root ganglion ; dorsal spinal cord ; sciatic nerve transection ; gene expression regulation ; SYNAPTIC VESICLE PROTEIN ; DORSAL-ROOT GANGLION ; NEUROPATHIC PAIN ; MESSENGER-RNA ; NEUROMUSCULAR SYNAPSES ; POSTNATAL-DEVELOPMENT ; HIPPOCAMPAL-NEURONS ; EXOCYTOTIC RELEASE ; MEMBRANE-PROTEINS ; GENE-EXPRESSION
Subject: Neurosciences & Neurology
Corresponding Author: Zhang, X (reprint author), Chinese Acad Sci, Inst Neurosci, Key Lab Neurobiol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,xu.zhang@ion.ac.cn
English Abstract: Synaptoporin and synaptophysin are integral membrane components of synaptic vesicles. The distribution of synaptoporin and its relationship with synaptophysin in sensory afferent fibers remain unclear. In the present study, we showed that in the rat dorsal root ganglia synaptoporin was expressed in subsets of small neurons that contain either calcitonin gene-related peptide or isolectin B4, and was distributed in their afferent terminals in laminae I-II of the spinal cord. Synaptophysin was expressed in 57% of synaptoporin-containing small dorsal root ganglion neurons and in large dorsal root ganglion neurons. In the spinal dorsal horn, synaptophysin-immunolabeling was weak in the afferent fibers in lamina I, outer lamina II and the dorsal part of inner lamina II, but strong in the afferent fibers in laminae III-IV. However, a subpopulation of isolectin B4-positive small dorsal root ganglion neurons expressed both synaptoporin and synaptophysin, and their afferent fibers were mainly distributed in the ventral part of inner lamina II. After peripheral nerve injury, synaptoporin expression was up-regulated in small dorsal root ganglion neurons, and synaptoporin level was increased in their afferent terminals. Thus, synaptoporin and synaptophysin have topographically distinct distributions in afferent fibers. Synaptoporin is a major synaptic vesicle protein in A delta- and C-fibers in both physiological and neuropathic pain states. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1849
Appears in Collections:神经所(总)_期刊论文
感觉系统研究组_期刊论文

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Recommended Citation:
Sun, T.; Xiao, H-S.; Zhou, P-B.; Lu, Y-J.; Bao, L.; Zhang, X..Differential expression of synaptoporin and synaptophysin in primary sensory neurons and up-regulation of synaptoporin after peripheral nerve injury,NEUROSCIENCE,2006,141(3):1233-1245
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