中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: N-acetylcysteine inhibit the translocation of mixed lineage kinase-3 from cytosol to plasma membrane during transient brain ischemia in rat hippocampus
Author: Pei, DS ; Guan, QH ; Sun, YF ; Zhang, QX ; Xu, TL(徐天乐) ; Zhang, GY
Source: NEUROSCIENCE LETTERS
Issued Date: 2005
Volume: 391, Issue:40910, Pages:38-42
Keyword: cerebral ischemia ; mixed lineage kinase-3 (MLK3) ; postsynaptic density protein 95 (PSD-95) ; N-acetylcysteine (NAC) ; POSTSYNAPTIC DENSITY PROTEIN-95 ; CEREBRAL-ISCHEMIA ; ACTIVATION ; IDENTIFICATION ; PHOSPHORYLATION ; SPRK ; PATHWAY ; BEARING ; FAMILY ; REGION
Subject: Neurosciences & Neurology
Corresponding Author: Zhang, GY (reprint author), Univ Sci & Technol China, Sch Life Sci, Dept Neurobiol & Biophys, Hefei 230027, Peoples R China,gyzhang@xzmc.edu.cn
English Abstract: Mixed lineage kinase-3 (MLK3) is a recently described member of the MLK subfamily of Ser/Thr protein kinases that interacts with mitogen-activated protein kinase (MAPK) pathways. In this study, we investigated the translocation of MLK3 during transient cerebral ischemia in rat hippocampus. Transient brain ischernia was induced by the four-vessel occlusion in Sprague-Dawley rats. Our data show that MLK3 can translocate from cytosolic fraction to the membrane fraction during ischernia and the increased MLK3 in the membrane fraction bind to postsynaptic density protein 95 (PSD-95). The antioxidant N-acetylcysteine (NAC) could inhibit the translocation of MLK3 from cytosolic fraction to the membrane fraction and decrease the interactions of MLK3 and PSD-95 in the membrane fraction. Consequently, these results indicate that reactive oxygen species (ROS) was closely associated with MLK3 translocation induced by transient global ischernia in rat hippocampus. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1858
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Pei-2005-N-acetylcysteine inh.pdf(213KB)----开放获取View Download

Recommended Citation:
Pei, DS; Guan, QH; Sun, YF; Zhang, QX; Xu, TL; Zhang, GY.N-acetylcysteine inhibit the translocation of mixed lineage kinase-3 from cytosol to plasma membrane during transient brain ischemia in rat hippocampus,NEUROSCIENCE LETTERS,2005,391(40910):38-42
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Pei, DS]'s Articles
[Guan, QH]'s Articles
[Sun, YF]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Pei, DS]‘s Articles
[Guan, QH]‘s Articles
[Sun, YF]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Pei-2005-N-acetylcysteine inh.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!