中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Gene array analysis to determine the components of neuropathic pain signaling
Author: null(张 旭) ; Xiao, HS
Source: CURRENT OPINION IN MOLECULAR THERAPEUTICS
Issued Date: 2005
Volume: 7, Issue:6, Pages:532-537
Keyword: dorsal root ganglion ; gene expression ; nerve injury ; pain ; spinal cord ; DORSAL-ROOT GANGLION ; PERIPHERAL-NERVE INJURY ; SPINAL-CORD ; CALCIUM-CHANNEL ; SENSORY NEURONS ; SODIUM-CHANNELS ; RATS ; AXOTOMY ; MODEL ; EXPRESSION
Subject: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
Corresponding Author: Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Lab Sensory Syst, Shanghai 200031, Peoples R China,xu.zhang@ion.ac.cn
English Abstract: The molecular modification of the pain pathway represents one of the major mechanisms underlying neuropathic pain. Recently, gene array studies have been carried out to identify the genes that are regulated at the spinal cord level after peripheral nerve injury. These studies demonstrate that peripheral nerve injury causes marked changes in gene expression in both the dorsal root ganglion (DRG) and the dorsal spinal cord. The markedly regulated molecules include, for example, neuropeptides, receptors, ion channels, signal transduction molecules and synaptic vesicle proteins. Upregulation of the Ca2+ channel alpha 2/delta 1 subunit, gamma-aminobutyric acid A receptor alpha 5 subunit, Na+ channels and nicotinic acetylcholine receptors in the DRG and dorsal spinal cord indicates their potential roles in neuropathic pain control.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1860
Appears in Collections:神经所(总)_期刊论文
感觉系统研究组_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
d1208010061yk01.pdf(1449KB)----开放获取View Download

Recommended Citation:
Zhang, X; Xiao, HS.Gene array analysis to determine the components of neuropathic pain signaling,CURRENT OPINION IN MOLECULAR THERAPEUTICS,2005,7(6):532-537
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, X]'s Articles
[Xiao, HS]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, X]‘s Articles
[Xiao, HS]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: d1208010061yk01.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!