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Title: Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation
Author: Wu, LJ ; Toyoda, H ; Zhao, MG ; Lee, YS ; Tang, JR ; Ko, SW ; Jia, YH ; Shum, FWF ; Zerbinatti, CV ; Bu, GJ ; Wei, F ; Xu, TL(徐天乐) ; Muglia, LJ ; Chen, ZF ; Auberson, YP ; Kaang, BK ; Zhuo, M
Source: JOURNAL OF NEUROSCIENCE
Issued Date: 2005
Volume: 25, Issue:48, Pages:11107-11116
Keyword: NMDA receptors ; NR2B ; anterior cingulate cortex ; inflammation ; pain ; hyperalgesia ; ANTERIOR CINGULATE CORTEX ; LONG-TERM-POTENTIATION ; D-ASPARTATE RECEPTORS ; MOTOR PROTEIN KIF17 ; GLUTAMATE RECEPTORS ; TYROSINE PHOSPHORYLATION ; DORSAL-HORN ; PHARMACOLOGICAL CHARACTERIZATION ; SYNAPTIC PLASTICITY ; GENETIC ENHANCEMENT
Subject: Neurosciences & Neurology
Corresponding Author: Zhuo, M (reprint author), Univ Toronto, Dept Physiol, Fac Med, Ctr Study Pain, Med Sci Bldg,Room 3342,1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada,min.zhuo@utoronto.ca
English Abstract: Transgenic overexpression of NMDA NR2B receptors in forebrain regions increased behavioral responses to persistent inflammatory pain. However, it is not known whether inflammation leads to the upregulation of NR2B receptors in these regions. Here, we show that peripheral inflammation increased the expression of NMDA NR2B receptors and NR2B receptor-mediated synaptic currents in the anterior cingulate cortex (ACC). In freely moving mice, the increase in NR2B receptors after inflammation contributed to enhanced NMDA receptor-mediated responses in the ACC. Inhibition of NR2B receptors in the ACC selectively reduced behavioral sensitization related to inflammation. Our results demonstrate that the upregulation of NR2B receptors in the ACC contributes to behavioral sensitization caused by inflammation.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1864
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Wu, LJ; Toyoda, H; Zhao, MG; Lee, YS; Tang, JR; Ko, SW; Jia, YH; Shum, FWF; Zerbinatti, CV; Bu, GJ; Wei, F; Xu, TL; Muglia, LJ; Chen, ZF; Auberson, YP; Kaang, BK; Zhuo, M.Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation,JOURNAL OF NEUROSCIENCE,2005,25(48):11107-11116
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