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Title: Kiss-and-run glutamate secretion in cultured and freshly isolated rat hippocampal astrocytes
Author: Chen, XK ; Wang, LC ; Zhou, Y ; Zheng, LH ; Zhou, Z(周专)
Source: JOURNAL OF NEUROSCIENCE
Issued Date: 2005
Volume: 25, Issue:40, Pages:9236-9243
Keyword: kiss-and-run ; fusion pore ; amperometry ; single-vesicle FM imaging ; glutamate ; freshly isolated astrocyte ; ADRENAL CHROMAFFIN CELLS ; SINGLE SYNAPTIC VESICLES ; AMPEROMETRIC DETECTION ; TRANSMITTER RELEASE ; QUANTAL SECRETION ; FUSION ; GLIA ; EXOCYTOSIS ; NEURONS ; CALCIUM
Subject: Neurosciences & Neurology
Corresponding Author: Zhou, Z (reprint author), Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China,zzhou@pku.edu.cn
English Abstract: Under physiological conditions, astrocytes not only passively support and nourish adjacent neurons, but also actively modulate neuronal transmission by releasing "glial transmitters," such as glutamate, ATP, and D-serine. Unlike the case for neurons, the mechanisms by which glia release transmitters are essentially unknown. Here, by using electrochemical amperometry and frequency-modulated single-vesicle imaging, we discovered that hippocampal astrocytes exhibit two modes of exocytosis of glutamate in response to various stimuli. After physiological stimulation, a glial vesicle releases a quantal content that is only 10% of that induced by nonphysiological, mechanical stimulation. The small release event arises from a brief (similar to 2 ms) opening of the fusion pore. We conclude that, after physiological stimulation, astrocytes release glutamate via a vesicular "kiss-and-run" mechanism.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1880
Appears in Collections:神经所(总)_期刊论文

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Chen, XK; Wang, LC; Zhou, Y; Zheng, LH; Zhou, Z.Kiss-and-run glutamate secretion in cultured and freshly isolated rat hippocampal astrocytes,JOURNAL OF NEUROSCIENCE,2005,25(40):9236-9243
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