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Title: Agrin regulates growth cone turning of Xenopus spinal motoneurons
Author: Xu, XH ; Fu, AKY ; Ip, FCF ; Wu, CP ; Duan, SM ; null(蒲慕明) ; Yuan, XB ; Ip, NY
Source: DEVELOPMENT
Issued Date: 2005
Volume: 132, Issue:19, Pages:4309-4316
Keyword: axon guidance ; neurite outgrowth ; pI3-kinase ; Rac1 ; calcium signaling
Subject: Developmental Biology
Corresponding Author: Ip, NY (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China,boip@ust.hk
English Abstract: The pivotal role of agrin in inducing postsynaptic specializations at neuromuscular junctions has been well characterized. Increasing evidence suggests that agrin is also involved in neuronal development. In this study, we found that agrin inhibited neurite extension and, more importantly, a gradient of agrin induced repulsive growth-cone turning in cultured Xenopus spinal neurons. Incubation with a neutralizing antibody to agrin or expression of the extracellular domain of muscle-specific kinase, a component of the agrin receptor complex, abolished these effects of agrin. Agrin-induced repulsive growth-cone turning requires the activity of PI3-kinase and Ca2+ signaling. In addition, the expression of dominant-negative Rac1 inhibited neurite extension and blocked agrin-mediated growth-cone turning. Taken together, our findings suggest that agrin regulates neurite extension and provide evidence for an unanticipated role of agrin in growth-cone steering in developing neurons.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1882
Appears in Collections:神经所(总)_期刊论文
神经可塑性研究组_期刊论文

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Xu, XH; Fu, AKY; Ip, FCF; Wu, CP; Duan, SM; Poo, MM; Yuan, XB; Ip, NY.Agrin regulates growth cone turning of Xenopus spinal motoneurons,DEVELOPMENT,2005,132(19):4309-4316
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