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Title: Activation of GPCRs modulates quantal size in chromaffin cells through G(beta gamma) and PKC
Author: Chen, XK ; Wang, LC ; Zhou, Y ; Cai, Q ; Prakriya, M ; Duan, KL ; Sheng, ZH ; Lingle, C ; Zhou, Z
Source: NATURE NEUROSCIENCE
Issued Date: 2005
Volume: 8, Issue:9, Pages:1160-1168
Keyword: PROTEIN-KINASE-C ; FUSION PORE KINETICS ; BETA-GAMMA-SUBUNITS ; TRANSMITTER RELEASE ; NEUROTRANSMITTER RELEASE ; PRESYNAPTIC INHIBITION ; SECRETORY GRANULES ; VESICLE FUSION ; EXOCYTOSIS ; RECEPTOR
Subject: Neurosciences & Neurology
Corresponding Author: Zhou, Z (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,zzhou@pku.edu.cn
English Abstract: Exocytosis proceeds by either full fusion or 'kiss-and-run' between vesicle and plasma membrane. Switching between these two modes permits the cell to regulate the kinetics and amount of secretion. Here we show that ATP receptor activation reduces secretion downstream from cytosolic Ca2+ elevation in rat adrenal chromaffin cells. This reduction is mediated by activation of a pertussis toxin - sensitive G(i/o) protein, leading to activation of G(beta gamma) subunits, which promote the `kiss-and-run' mode by reducing the total open time of the fusion pore during a vesicle fusion event. Furthermore, parallel activation of the muscarinic acetylcholine receptor removes the inhibitory effects of ATP on secretion. This is mediated by a G(q) pathway through protein kinase C activation. The inhibitory effects of ATP and its reversal by protein kinase C activation are also shared by opioids and somatostatin. Thus, a variety of G protein pathways exist to modulate Ca2+-evoked secretion at specific steps in fusion pore formation.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1887
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Chen, XK; Wang, LC; Zhou, Y; Cai, Q; Prakriya, M; Duan, KL; Sheng, ZH; Lingle, C; Zhou, Z.Activation of GPCRs modulates quantal size in chromaffin cells through G(beta gamma) and PKC,NATURE NEUROSCIENCE,2005,8(9):1160-1168
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