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Title: Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia
Author: Guan, JS ; Xu, ZZ ; Gao, H ; He, SQ ; Ma, GQ ; Sun, T ; Wang, LH ; Zhang, ZN ; Lena, I ; Kitchen, I ; Elde, R ; Zimmer, A ; He, C ; Pei, G ; Bao, L ; null(张 旭)
Source: CELL
Issued Date: 2005
Volume: 122, Issue:4, Pages:619-631
Keyword: SECRETORY GRANULE BIOGENESIS ; PROTEIN-COUPLED RECEPTOR ; ROOT GANGLION NEURONS ; RAT SPINAL-CORD ; SUBSTANCE-P ; PHARMACOLOGICAL CHARACTERIZATION ; PHYSICAL-DEPENDENCE ; PERIPHERAL AXOTOMY ; KNOCKOUT MICE ; MU
Subject: Biochemistry & Molecular Biology ; Cell Biology
Corresponding Author: Zhang, X (reprint author), Chinese Acad Sci, Inst Neurosci, Key Lab Neurobiol, Shanghai 200031, Peoples R China,xu.zhang@ion.ac.cn
English Abstract: Opioid and tachykinin systems are involved in modulation of pain transmission in the spinal cord. Regulation of surface opioid receptors on nociceptive afferents is critical for opioid analgesia. Plasma-membrane insertion of delta-opioid receptors (DORs) is induced by stimulus-triggered exocytosis of DOR-containing large dense-core vesicles (LDCVs), but how DORs become sorted into the regulated secretory pathway is unknown. Here we report that direct interaction between protachykinin and DOR is responsible for sorting of DORs into LDCVs, allowing stimulus-induced surface insertion of DORs and DOR-mediated spinal analgesia. This interaction is mediated by the substance P domain of protachykinin and the third luminal domain of DOR. Furthermore, deletion of the preprotachykinin A gene reduced stimulus-induced surface insertion of DORs and abolished DOR-mediated spinal analgesia and morphine tolerance. Thus, protachylkinin is essential for modulation of the sensitivity of nociceptive afferents to opioids, and the opioid and tachykinin systems are directly linked by protachykinin/DOR interaction.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1888
Appears in Collections:神经所(总)_期刊论文
感觉系统研究组_期刊论文

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Recommended Citation:
Guan, JS; Xu, ZZ; Gao, H; He, SQ; Ma, GQ; Sun, T; Wang, LH; Zhang, ZN; Lena, I; Kitchen, I; Elde, R; Zimmer, A; He, C; Pei, G; Bao, L; Zhang, X.Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia,CELL,2005,122(4):619-631
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